ENSMUSG00000027845


Mus musculus

Features
Gene ID: ENSMUSG00000027845
  
Biological name :Dclre1b
  
Synonyms : 5 exonuclease Apollo / Dclre1b / Q8C7W7
  
Possible biological names infered from orthology : DNA cross-link repair 1B / Q9H816
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 103800605
Gene end: 103809444
  
Corresponding Affymetrix probe sets: 10500837 (MoGene1.0st)   1440383_at (Mouse Genome 430 2.0 Array)   1440667_at (Mouse Genome 430 2.0 Array)   1448520_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102447
Ensembl peptide - ENSMUSP00000143067
Ensembl peptide - ENSMUSP00000121063
Ensembl peptide - ENSMUSP00000029435
Ensembl peptide - ENSMUSP00000067695
Ensembl peptide - ENSMUSP00000102445
NCBI entrez gene - 140917     See in Manteia.
MGI - MGI:2156057
RefSeq - NM_001025312
RefSeq - NM_133865
RefSeq Peptide - NP_001020483
RefSeq Peptide - NP_598626
swissprot - Q8C7W7
swissprot - A0A0G2JF86
swissprot - D6RFP8
Ensembl - ENSMUSG00000027845
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0V2S2ENSDARG00000068833Danio rerio
 DCLRE1BENSGALG00000028626Gallus gallus
 Q9H816ENSG00000118655Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*ENSMUSG0000002664824
Dclre1a / DNA cross-link repair 1A / Q6PJP8*ENSMUSG000000250779


Protein motifs (from Interpro)
Interpro ID Name
 IPR001279  Metallo-beta-lactamase
 IPR011084  DNA repair metallo-beta-lactamase
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000075 cell cycle checkpoint ISS
 biological_processGO:0000723 telomere maintenance ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair ISA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010833 telomere maintenance via telomere lengthening ISO
 biological_processGO:0016233 telomere capping ISO
 biological_processGO:0031627 telomeric loop formation IMP
 biological_processGO:0031848 protection from non-homologous end joining at telomere IMP
 biological_processGO:0031860 telomeric 3" overhang formation IMP
 biological_processGO:0036297 interstrand cross-link repair IBA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IBA
 cellular_componentGO:0005634 nucleus ISA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008409 5"-3" exonuclease activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035312 5"-3" exodeoxyribonuclease activity IBA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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