ENSMUSG00000090083


Mus musculus

Features
Gene ID: ENSMUSG00000090083
  
Biological name :Rnf8
  
Synonyms : E3 ubiquitin-protein ligase RNF8 / Q8VC56 / Rnf8
  
Possible biological names infered from orthology : O76064 / ring finger protein 8
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 29614790
Gene end: 29641664
  
Corresponding Affymetrix probe sets: 10443550 (MoGene1.0st)   1424120_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124566
Ensembl peptide - ENSMUSP00000133424
Ensembl peptide - ENSMUSP00000134697
Ensembl peptide - ENSMUSP00000024817
NCBI entrez gene - 58230     See in Manteia.
MGI - MGI:1929069
RefSeq - NM_021419
RefSeq Peptide - NP_067394
swissprot - Q8VC56
swissprot - E0CY08
swissprot - G3UWU4
swissprot - G3UZZ4
Ensembl - ENSMUSG00000090083
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf8ENSDARG00000044949Danio rerio
 RNF8ENSGALG00000023256Gallus gallus
 RNF8ENSG00000112130Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm28043 / RNF8* / O76064* / ring finger protein 8*ENSMUSG0000009837499


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001841  Zinc finger, RING-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017335  E3 ubiquitin-protein ligase RNF8
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISS
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0010212 response to ionizing radiation ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033522 histone H2A ubiquitination ISO
 biological_processGO:0033523 histone H2B ubiquitination IMP
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter ISS
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IMP
 biological_processGO:0043486 histone exchange IMP
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0070534 protein K63-linked ubiquitination ISO
 biological_processGO:0070535 histone H2A K63-linked ubiquitination ISO
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 cellular_componentGO:0000151 ubiquitin ligase complex ISS
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0035861 site of double-strand break ISS
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042393 histone binding IMP
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IMP


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / complex / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction / complex
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / complex / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr