ENSMUSG00000031928


Mus musculus

Features
Gene ID: ENSMUSG00000031928
  
Biological name :Mre11a
  
Synonyms : Double-strand break repair protein MRE11 / Mre11a / Q61216
  
Possible biological names infered from orthology : MRE11 / MRE11 homolog, double strand break repair nuclease / P49959
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A2
Gene start: 14784654
Gene end: 14837123
  
Corresponding Affymetrix probe sets: 10583264 (MoGene1.0st)   1416748_a_at (Mouse Genome 430 2.0 Array)   1441990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034405
Ensembl peptide - ENSMUSP00000116321
Ensembl peptide - ENSMUSP00000119999
Ensembl peptide - ENSMUSP00000149184
Ensembl peptide - ENSMUSP00000111295
NCBI entrez gene - 17535     See in Manteia.
MGI - MGI:1100512
RefSeq - XM_006510054
RefSeq - NM_001310728
RefSeq - NM_018736
RefSeq - XM_006510048
RefSeq - XM_006510049
RefSeq - XM_006510051
RefSeq - XM_006510052
RefSeq - XM_006510053
RefSeq Peptide - NP_061206
RefSeq Peptide - NP_001297657
swissprot - Q61216
swissprot - F6RX99
swissprot - Q3URU4
swissprot - A0A1L1SQT7
swissprot - B2KF76
Ensembl - ENSMUSG00000031928
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mre11aENSDARG00000105014Danio rerio
 MRE11ENSGALG00000017211Gallus gallus
 MRE11ENSG00000020922Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003701  DNA double-strand break repair protein Mre11
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR007281  Mre11, DNA-binding
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007062 sister chromatid cohesion ISO
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IMP
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0031573 intra-S DNA damage checkpoint IMP
 biological_processGO:0031860 telomeric 3" overhang formation ISO
 biological_processGO:0031954 positive regulation of protein autophosphorylation ISO
 biological_processGO:0032206 positive regulation of telomere maintenance ISO
 biological_processGO:0032508 DNA duplex unwinding ISO
 biological_processGO:0032876 negative regulation of DNA endoreduplication ISO
 biological_processGO:0033674 positive regulation of kinase activity ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0030870 Mre11 complex ISO
 cellular_componentGO:0035861 site of double-strand break ISO
 molecular_functionGO:0000014 single-stranded DNA endodeoxyribonuclease activity ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity ISO
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity ISO
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008408 3"-5" exonuclease activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Cytosolic sensors of pathogen-associated DNA
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: En1tm1Gld/En1tm1Gld
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: En1tm1Gld/En1tm1Gld
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster

Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Mre11atm1Jpt/Mre11atm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Mre11atm1Jpt/Mre11a+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Megf10tm1a(KOMP)Jrs/Megf10+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: En1tm1Gld/En1tm1Gld
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: En1tm1Gld/En1tm1Gld
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11a+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Mre11atm1Dof/Mre11atm2.1Dof
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Dof/Mre11atm2.1Dof
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Mre11atm1Jpt/Mre11atm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Mre11atm1Jpt/Mre11atm1Jpt
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Mre11atm1Dof/Mre11atm2.1Dof
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Mre11atm1Dof/Mre11atm2.1Dof
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Mre11atm1Jpt/Mre11atm1Jpt
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: En1tm1Gld/En1tm1Gld
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Mre11atm1Jpt/Mre11atm1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mre11atm1Jpt/Mre11a+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / reaction / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000028886 Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*  / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / complex / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / reaction / complex
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / complex / reaction
 ENSMUSG00000031583 Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / complex / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / reaction / complex
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / complex / reaction
 ENSMUSG00000034206 Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / reaction / complex
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / complex / reaction
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000037032 Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction / complex
 ENSMUSG00000051768 Xrcc1 / Q60596 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / X-ray repair cross complementing 1*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

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