ENSMUSG00000037032


Mus musculus

Features
Gene ID: ENSMUSG00000037032
  
Biological name :Apbb1
  
Synonyms : Amyloid-beta A4 protein-binding family B member 1 / Apbb1 / Q9QXJ1
  
Possible biological names infered from orthology : amyloid beta precursor protein binding family B member 1 / O00213
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 105558483
Gene end: 105581653
  
Corresponding Affymetrix probe sets: 10566457 (MoGene1.0st)   1423892_at (Mouse Genome 430 2.0 Array)   1423893_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139755
Ensembl peptide - ENSMUSP00000139575
Ensembl peptide - ENSMUSP00000139788
Ensembl peptide - ENSMUSP00000148234
Ensembl peptide - ENSMUSP00000147947
Ensembl peptide - ENSMUSP00000147609
Ensembl peptide - ENSMUSP00000147397
Ensembl peptide - ENSMUSP00000140979
Ensembl peptide - ENSMUSP00000140973
Ensembl peptide - ENSMUSP00000140822
Ensembl peptide - ENSMUSP00000140715
Ensembl peptide - ENSMUSP00000140486
Ensembl peptide - ENSMUSP00000140192
Ensembl peptide - ENSMUSP00000140137
Ensembl peptide - ENSMUSP00000140116
Ensembl peptide - ENSMUSP00000140052
Ensembl peptide - ENSMUSP00000139899
Ensembl peptide - ENSMUSP00000079932
Ensembl peptide - ENSMUSP00000139426
NCBI entrez gene - 11785     See in Manteia.
MGI - MGI:107765
RefSeq - XM_017321947
RefSeq - NM_001253885
RefSeq - NM_001253886
RefSeq - NM_001253887
RefSeq - NM_001310600
RefSeq - NM_009685
RefSeq - XM_006507230
RefSeq - XM_006507231
RefSeq - XM_006507232
RefSeq - XM_006507234
RefSeq - XM_006507235
RefSeq - XM_006507236
RefSeq - XM_017321946
RefSeq Peptide - NP_001297529
RefSeq Peptide - NP_001240814
RefSeq Peptide - NP_001240815
RefSeq Peptide - NP_033815
RefSeq Peptide - NP_001240816
swissprot - A0A1B0GT76
swissprot - A0A1B0GSI3
swissprot - A0A1B0GRP5
swissprot - A0A1B0GR67
swissprot - A0A0R4J2C6
swissprot - A0A0R4J2C1
swissprot - A0A087WRY7
swissprot - A0A087WRP1
swissprot - A0A087WR62
swissprot - A0A087WQH0
swissprot - A0A087WQC5
swissprot - A0A087WPS7
swissprot - A0A087WQ58
swissprot - A0A087WPI2
swissprot - A0A087WPF4
swissprot - Q9QXJ1
swissprot - A0A087WNN4
Ensembl - ENSMUSG00000037032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apbb1ENSDARG00000076560Danio rerio
 APBB1ENSGALG00000046164Gallus gallus
 APBB1ENSG00000166313Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apbb2 / Q9DBR4 / Amyloid-beta A4 protein-binding family B member 2 / Q92870* / amyloid beta precursor protein binding family B member 2*ENSMUSG0000002920742
Sra1 / Q8R1C9 / Q80VJ2 / Mus musculus amyloid beta (A4) protein-binding, family B, member 3 (Apbb3), transcript variant 2, mRNA. / APBB3* / O95704* / amyloid beta precursor protein binding ...ENSMUSG0000000605021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007411 axon guidance IGI
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0030048 actin filament-based movement NAS
 biological_processGO:0030198 extracellular matrix organization IGI
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043967 histone H4 acetylation ISS
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050760 negative regulation of thymidylate synthase biosynthetic process IDA
 biological_processGO:0050821 protein stabilization NAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044304 main axon IEA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1990761 growth cone lamellipodium IEA
 cellular_componentGO:1990812 growth cone filopodium IEA
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0035035 histone acetyltransferase binding NAS
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0070064 proline-rich region binding ISO


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000794 abnormal parietal lobe morphology "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

Allelic Composition: Apbb1tm1Quhu/Apbb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Apbb1tm1Her/Apbb1+,Apbb2tm1Her/Apbb2tm1Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Apbb1tm1Her/Apbb1tm1Her,Apbb2tm1Her/Apbb2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

Allelic Composition: Apbb1tm1Quhu/Apbb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

 MP:0005623 abnormal meninges "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0009026 abnormal brain pia mater morphology "any structural anomaly of the fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction / complex
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction






 

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