ENSMUSG00000006050


Mus musculus

Features
Gene ID: ENSMUSG00000006050
  
Biological name :Sra1
  
Synonyms : Mus musculus amyloid beta (A4) protein-binding, family B, member 3 (Apbb3), transcript variant 2, mRNA. / Q80VJ2 / Q8R1C9 / Sra1
  
Possible biological names infered from orthology : amyloid beta precursor protein binding family B member 3 / APBB3 / O95704
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 36666681
Gene end: 36679366
  
Corresponding Affymetrix probe sets: 10458349 (MoGene1.0st)   10458355 (MoGene1.0st)   1424457_at (Mouse Genome 430 2.0 Array)   1437423_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006209
Ensembl peptide - ENSMUSP00000001415
Ensembl peptide - ENSMUSP00000133360
Ensembl peptide - ENSMUSP00000134589
NCBI entrez gene - 24068     See in Manteia.
NCBI entrez gene - 225372     See in Manteia.
MGI - MGI:1344414
RefSeq - XM_006525861
RefSeq - NM_001164406
RefSeq - NM_001357512
RefSeq - NM_025291
RefSeq - NM_146085
RefSeq Peptide - NP_001157878
RefSeq Peptide - NP_001344441
RefSeq Peptide - NP_079567
RefSeq Peptide - NP_666197
swissprot - G3UZQ4
swissprot - Q8R1C9
swissprot - G3X8R2
swissprot - Q3UR23
swissprot - Q80VJ2
Ensembl - ENSMUSG00000006050
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apbb3ENSDARG00000053771Danio rerio
 ENSGALG00000001132Gallus gallus
 APBB3ENSG00000113108Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apbb2 / Q9DBR4 / Amyloid-beta A4 protein-binding family B member 2 / Q92870* / amyloid beta precursor protein binding family B member 2*ENSMUSG0000002920733
Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*ENSMUSG0000003703231


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR006020  PTB/PI domain
 IPR009917  Steroid receptor RNA activator-protein/coat protein complex II, Sec31
 IPR011993  PH-like domain superfamily
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0030154 cell differentiation ISO
 biological_processGO:0042981 regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005831 steroid hormone aporeceptor complex ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0045171 intercellular bridge ISO
 molecular_functionGO:0001540 amyloid-beta binding IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003712 transcription coregulator activity ISO
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0003795 abnormal bone structure 
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0009136 decreased brown fat cell size "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0010360 decreased liver free fatty acids level "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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