ENSMUSG00000029207


Mus musculus

Features
Gene ID: ENSMUSG00000029207
  
Biological name :Apbb2
  
Synonyms : Amyloid-beta A4 protein-binding family B member 2 / Apbb2 / Q9DBR4
  
Possible biological names infered from orthology : amyloid beta precursor protein binding family B member 2 / Q92870
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.1
Gene start: 66298703
Gene end: 66618784
  
Corresponding Affymetrix probe sets: 10530287 (MoGene1.0st)   1426719_at (Mouse Genome 430 2.0 Array)   1426720_at (Mouse Genome 430 2.0 Array)   1452342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123978
Ensembl peptide - ENSMUSP00000124127
Ensembl peptide - ENSMUSP00000125603
Ensembl peptide - ENSMUSP00000125550
Ensembl peptide - ENSMUSP00000125211
Ensembl peptide - ENSMUSP00000125116
Ensembl peptide - ENSMUSP00000124807
Ensembl peptide - ENSMUSP00000124350
Ensembl peptide - ENSMUSP00000124139
Ensembl peptide - ENSMUSP00000084511
Ensembl peptide - ENSMUSP00000123752
Ensembl peptide - ENSMUSP00000123766
Ensembl peptide - ENSMUSP00000123778
NCBI entrez gene - 11787     See in Manteia.
MGI - MGI:108405
RefSeq - XM_017320621
RefSeq - XM_006503690
RefSeq - XM_017320620
RefSeq - XM_011240693
RefSeq - XM_006503688
RefSeq - XM_006503694
RefSeq - XM_006503693
RefSeq - XM_006503692
RefSeq - XM_006503691
RefSeq - NM_001201413
RefSeq - NM_001201414
RefSeq - NM_001201415
RefSeq - NM_001310626
RefSeq - NM_009686
RefSeq - XM_017320622
RefSeq Peptide - NP_001188344
RefSeq Peptide - NP_001188342
RefSeq Peptide - NP_001188343
RefSeq Peptide - NP_001297555
RefSeq Peptide - NP_033816
swissprot - Q3TIZ5
swissprot - Q9DBR4
swissprot - Q3TDW6
swissprot - E9QPX0
swissprot - E0CYB2
swissprot - F6V8Y6
swissprot - E0CYJ4
swissprot - E0CYJ8
swissprot - E0CYY8
swissprot - E0CZ85
swissprot - E0CZA9
swissprot - E9PWH3
Ensembl - ENSMUSG00000029207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apbb2bENSDARG00000099995Danio rerio
 APBB2ENSGALG00000014262Gallus gallus
 APBB2ENSG00000163697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*ENSMUSG0000003703240
Sra1 / Q8R1C9 / Q80VJ2 / Mus musculus amyloid beta (A4) protein-binding, family B, member 3 (Apbb3), transcript variant 2, mRNA. / APBB3* / O95704* / amyloid beta precursor protein binding ...ENSMUSG0000000605021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007411 axon guidance IGI
 biological_processGO:0030048 actin filament-based movement NAS
 biological_processGO:0030198 extracellular matrix organization IGI
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0050821 protein stabilization NAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0001540 amyloid-beta binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0035035 histone acetyltransferase binding NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000794 abnormal parietal lobe morphology "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Apbb1tm1Her/Apbb1+,Apbb2tm1Her/Apbb2tm1Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Apbb1tm1Her/Apbb1tm1Her,Apbb2tm1Her/Apbb2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0005623 abnormal meninges "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0009026 abnormal brain pia mater morphology "any structural anomaly of the fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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