ENSMUSG00000028224


Mus musculus

Features
Gene ID: ENSMUSG00000028224
  
Biological name :Nbn
  
Synonyms : Nbn / Nibrin / Q9R207
  
Possible biological names infered from orthology : O60934
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A2
Gene start: 15957925
Gene end: 15992589
  
Corresponding Affymetrix probe sets: 10503431 (MoGene1.0st)   1448746_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029879
Ensembl peptide - ENSMUSP00000120829
NCBI entrez gene - 27354     See in Manteia.
MGI - MGI:1351625
RefSeq - XM_006537971
RefSeq - NM_013752
RefSeq - XM_006537970
RefSeq Peptide - NP_038780
swissprot - Q9R207
swissprot - A2AMG5
Ensembl - ENSMUSG00000028224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nbnENSDARG00000040303Danio rerio
 NBNENSGALG00000037686Gallus gallus
 NBNENSG00000104320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001357  BRCT domain
 IPR008984  SMAD/FHA domain superfamily
 IPR013908  DNA repair Nbs1, C-terminal
 IPR016592  Nibrin
 IPR032429  Nibrin, second BRCT domain
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001832 blastocyst growth IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0016233 telomere capping IBA
 biological_processGO:0031860 telomeric 3" overhang formation IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IBA
 biological_processGO:0045190 isotype switching IDA
 biological_processGO:0048145 regulation of fibroblast proliferation ISS
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090656 t-circle formation IEA
 biological_processGO:0090737 telomere maintenance via telomere trimming IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 biological_processGO:1904354 negative regulation of telomere capping IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0030870 Mre11 complex IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:0042405 nuclear inclusion body IEA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Trp53tm1Brd/Trp53+,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Trp53tm1Brd/Trp53+,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Foxe3rct/Foxe3rct
Genetic Background: SJL/J-Foxe3rct

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Trp53tm1Brd/Trp53+,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: ICR

Allelic Composition: Nbntm2.1Jpt/Nbn+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * 129/Sv

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Nbntm1Zqw/Nbntm1Zqw
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Nbntm1Jpt/Nbntm1Jpt
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Trp53tm1Brd/Trp53tm1Brd,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Trp53tm1Brd/Trp53tm1Brd,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm1Jpt/Nbntm1Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002627 teratoma "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nbntm1Jpt/Nbntm1Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003496 thyroid adenoma "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Nbntm1Jpt/Nbntm1Jpt
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nbntm1Jpt/Nbntm1Jpt
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: ICR

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic Background: involves: 129S6/SvEvTac * 129/Sv

Allelic Composition: Nbntm3Jpt/Nbntm3Jpt
Genetic Background: involves: 129/Sv

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Nbntm1Zqw/Nbntm1Zqw
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Prnptm1(PRNP)Tkit/Prnptm1(PRNP)Tkit
Genetic Background: Not Specified

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxe3rct/Foxe3rct
Genetic Background: SJL/J-Foxe3rct

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1(PRNP)Tkit/Prnptm1(PRNP)Tkit
Genetic Background: Not Specified

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbntm2.1Jpt/Nbntm2.1Jpt,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * 129/Sv

Allelic Composition: Nbntm2.1Jpt/Nbn+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd * 129/Sv

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009590 gonad tumor "presence of abnormal rapidly proliferating cells in the testis or ovary, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009591 liver adenocarcinoma "malignant neoplasm of epithelial cells in the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009592 Leydig cell tumor "rare testicular tumors of the male gonadal interstitium that are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm2Zqw/Nbntm2.1Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nbntm1Jpt/Nbntm1Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbntm1Zqw/Nbntm1Zqw
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Nbntm1Jpt/Nbntm1Jpt
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nbntm1Jpt/Nbntm1Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Nbntm1Zqw/Nbntm1Zqw
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Nbntm1Zqw/Nbntm1Zqw
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Nbntm1Zqw/Nbn+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nbntm2Zqw/Nbntm2Zqw,Trp53tm1Brd/Trp53tm1Brd,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Nbntm1Jpt/Nbntm1Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0013236 ovary degeneration "a retrogressive impairment of function or destruction of one or both ovaries" [MGI:anna]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / reaction / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000028886 Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*  / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction / complex
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSMUSG00000031583 Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000037032 Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*  / reaction / complex
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / reaction / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000018362 Kpna2 / P52293 / Importin subunit alpha-1 / P52292* / karyopherin subunit alpha 2*  / reaction / complex
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / reaction / complex
 ENSMUSG00000034206 Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*  / complex / reaction
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / complex / reaction
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / reaction / complex
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / complex / reaction
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / complex / reaction
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000051768 Xrcc1 / Q60596 / X-ray repair complementing defective repair in Chinese hamster cells 1 / P18887* / X-ray repair cross complementing 1*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex






 

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