Manteia - Molecule gene

ENSMUSG00000034206

Mus musculus

Features

Gene ID:	ENSMUSG00000034206

Biological name :	Polq

Synonyms :	Polq / polymerase (DNA directed), theta / Q8CGS6

Possible biological names infered from orthology :	DNA polymerase theta / O75417

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	B3
Gene start:	37011786
Gene end:	37095417

Corresponding Affymetrix probe sets:	10435581 (MoGene1.0st) 1453551_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000059757 Ensembl peptide - ENSMUSP00000071396 Ensembl peptide - ENSMUSP00000138648 Ensembl peptide - ENSMUSP00000138685 NCBI entrez gene - 77782 See in Manteia. MGI - MGI:2155399 RefSeq - XM_006522736 RefSeq - NM_001159369 RefSeq - NM_029977 RefSeq - XM_006522733 RefSeq - XM_006522734 RefSeq - XM_006522735 RefSeq Peptide - NP_001152841 RefSeq Peptide - NP_084253 swissprot - Q8CGS6 swissprot - Q80XB7 swissprot - Q8BGX6 Ensembl - ENSMUSG00000034206

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
polq	ENSDARG00000044622	Danio rerio
POLQ	ENSGALG00000014924	Gallus gallus
POLQ	ENSG00000051341	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q6P4T2 / Snrnp200 / U5 small nuclear ribonucleoprotein 200 kDa helicase / O75643* / small nuclear ribonucleoprotein U5 subunit 200*	ENSMUSG00000003660	11
Helq / Q2VPA6 / Helicase POLQ-like / Q8TDG4*	ENSMUSG00000035266	11
Poln / DNA polymerase N / Q7Z5Q5* / DNA polymerase nu*	ENSMUSG00000045102	10
Ascc3 / E9PZJ8 / Activating signal cointegrator 1 complex subunit 3 / Q8N3C0*	ENSMUSG00000038774	10

Protein motifs (from Interpro)

Interpro ID	Name
IPR001098	DNA-directed DNA polymerase, family A, palm domain
IPR001650	Helicase, C-terminal
IPR002298	DNA polymerase A
IPR011545	DEAD/DEAH box helicase domain
IPR012337	Ribonuclease H-like superfamily
IPR014001	Helicase superfamily 1/2, ATP-binding domain
IPR019760	DNA-directed DNA polymerase, family A, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006260	DNA replication	IEA
biological_process	GO:0006261	DNA-dependent DNA replication	IBA
biological_process	GO:0006281	DNA repair	IMP
biological_process	GO:0006284	base-excision repair	IEA
biological_process	GO:0006302	double-strand break repair	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	ISO
biological_process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP
biological_process	GO:0051260	protein homooligomerization	IEA
biological_process	GO:0071897	DNA biosynthetic process	IEA
biological_process	GO:0097681	double-strand break repair via alternative nonhomologous end joining	IDA
biological_process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005694	chromosome	IEA
cellular_component	GO:0005737	cytoplasm	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IEA
molecular_function	GO:0003887	DNA-directed DNA polymerase activity	ISO
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016779	nucleotidyltransferase activity	IEA
molecular_function	GO:0042802	identical protein binding	ISO
molecular_function	GO:0043142	single-stranded DNA-dependent ATPase activity	IEA
molecular_function	GO:0051575	5"-deoxyribose-5-phosphate lyase activity	IEA

Pathways (from Reactome)

Pathway description

HDR through MMEJ (alt-NHEJ)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polq^tm2Jow/Polq^tm2Jow Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polq^tm2Jow/Polq^tm2Jow Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002007	increased sensitivity to gamma-irradiation	"increased incidence of cell death following high levels of gamma-irradiation" [J:51834]	Show Allelic Composition: Lrit3^tvrm257/Lrit3^tvrm257 Genetic Background: B6.Cg-Lrit3^tvrm257/Pjn
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polq^tm2Jow/Polq^tm2Jow Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002460	decreased circulating immunoglobulin concentration	"less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polq^tm2Jow/Polq^tm2Jow Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004028	chromosome breakage	"chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak,Tnfsf9^tm1Thw/Tnfsf9^tm1Thw Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
MP:0004815	abnormal somatic hypermutation frequency	"any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wnt1^tm1Mrc/Wnt1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Polq^tm2Jow/Polq^tm2Jow Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Polq^tm1Jow/Polq^tm1Jow Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Polq^tm1Jow/Polq^tm1Jow Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020380	Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*	/ complex / reaction
ENSMUSG00000024742	Fen1 / flap structure-specific endonuclease 1 / P39748*	/ complex / reaction
ENSMUSG00000028224	Nbn / Q9R207 / Nibrin / O60934*	/ reaction / complex
ENSMUSG00000031928	Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*	/ complex / reaction
ENSMUSG00000041238	Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*	/ complex / reaction
ENSMUSG00000026496	Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*	/ complex / reaction
ENSMUSG00000034206	Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr