ENSMUSG00000035266


Mus musculus

Features
Gene ID: ENSMUSG00000035266
  
Biological name :Helq
  
Synonyms : Helicase POLQ-like / Helq / Q2VPA6
  
Possible biological names infered from orthology : Q8TDG4
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E4
Gene start: 100762145
Gene end: 100798598
  
Corresponding Affymetrix probe sets: 10531752 (MoGene1.0st)   1427554_at (Mouse Genome 430 2.0 Array)   1435451_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041599
Ensembl peptide - ENSMUSP00000116470
Ensembl peptide - ENSMUSP00000118493
Ensembl peptide - ENSMUSP00000120806
NCBI entrez gene - 191578     See in Manteia.
MGI - MGI:2176740
RefSeq - XM_017320728
RefSeq - XM_006534826
RefSeq - XM_006534827
RefSeq - XM_006534828
RefSeq - XM_006534829
RefSeq - XM_017320727
RefSeq - NM_001081107
RefSeq - XM_006534822
RefSeq - XM_006534823
RefSeq Peptide - NP_001074576
swissprot - F7DCU7
swissprot - F6VYI2
swissprot - Q2VPA6
swissprot - Q8BKT5
Ensembl - ENSMUSG00000035266
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 helqENSDARG00000079818Danio rerio
 ENSGALG00000043261Gallus gallus
 ENSGALG00000011208Gallus gallus
 HELQENSG00000163312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*ENSMUSG0000003420626
Q6P4T2 / Snrnp200 / U5 small nuclear ribonucleoprotein 200 kDa helicase / O75643* / small nuclear ribonucleoprotein U5 subunit 200*ENSMUSG0000000366017
Ascc3 / E9PZJ8 / Activating signal cointegrator 1 complex subunit 3 / Q8N3C0*ENSMUSG0000003877416
Poln / DNA polymerase N / Q7Z5Q5* / DNA polymerase nu*ENSMUSG000000451025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006259 DNA metabolic process ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010288 increased gland tumor incidence "greater than the expected number of tumors originating in a gland in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012437 increased Harderian gland tumor incidence "greater than the expected number of neoplams in the Harderian gland, usually in the form of a distinct mass, in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Hrrh-10J/Hrrh-10J
Genetic Background: C57BL/6J-Hrrh-10J/GrsrJ

Allelic Composition: HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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