ENSMUSG00000003660


Mus musculus

Features
Gene ID: ENSMUSG00000003660
  
Biological name :Snrnp200
  
Synonyms : Q6P4T2 / Snrnp200 / U5 small nuclear ribonucleoprotein 200 kDa helicase
  
Possible biological names infered from orthology : O75643 / small nuclear ribonucleoprotein U5 subunit 200
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 127208386
Gene end: 127240451
  
Corresponding Affymetrix probe sets: 10475718 (MoGene1.0st)   1454772_at (Mouse Genome 430 2.0 Array)   1460552_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099509
NCBI entrez gene - 320632     See in Manteia.
MGI - MGI:2444401
RefSeq - NM_177214
RefSeq - XM_017319022
RefSeq Peptide - NP_796188
swissprot - Q6P4T2
Ensembl - ENSMUSG00000003660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snrnp200ENSDARG00000077536Danio rerio
 O75643ENSG00000144028Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ascc3 / E9PZJ8 / Activating signal cointegrator 1 complex subunit 3 / Q8N3C0*ENSMUSG0000003877440
Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*ENSMUSG0000003420613
Helq / Q2VPA6 / Helicase POLQ-like / Q8TDG4*ENSMUSG000000352669
Poln / DNA polymerase N / Q7Z5Q5* / DNA polymerase nu*ENSMUSG000000451025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR004179  Sec63 domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014756  Immunoglobulin E-set
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035892  C2 domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex ISO
 cellular_componentGO:0005682 U5 snRNP IEA
 cellular_componentGO:0046540 U4/U6 x U5 tri-snRNP complex IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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