ENSMUSG00000038774


Mus musculus

Features
Gene ID: ENSMUSG00000038774
  
Biological name :Ascc3
  
Synonyms : Activating signal cointegrator 1 complex subunit 3 / Ascc3 / E9PZJ8
  
Possible biological names infered from orthology : Q8N3C0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B3
Gene start: 50592669
Gene end: 50851485
  
Corresponding Affymetrix probe sets: 10363007 (MoGene1.0st)   1457069_at (Mouse Genome 430 2.0 Array)   1457900_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036726
Ensembl peptide - ENSMUSP00000151983
Ensembl peptide - ENSMUSP00000151273
NCBI entrez gene - 77987     See in Manteia.
MGI - MGI:1925237
RefSeq - NM_198007
RefSeq - XM_006512923
RefSeq Peptide - NP_932124
swissprot - A0A1W2P891
swissprot - A0A1W2P6I6
swissprot - E9PZJ8
Ensembl - ENSMUSG00000038774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ASCC3ENSG00000112249Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6P4T2 / Snrnp200 / U5 small nuclear ribonucleoprotein 200 kDa helicase / O75643* / small nuclear ribonucleoprotein U5 subunit 200*ENSMUSG0000000366039
Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*ENSMUSG0000003420612
Helq / Q2VPA6 / Helicase POLQ-like / Q8TDG4*ENSMUSG000000352668
Poln / DNA polymerase N / Q7Z5Q5* / DNA polymerase nu*ENSMUSG000000451025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR003593  AAA+ ATPase domain
 IPR004179  Sec63 domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014756  Immunoglobulin E-set
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035892  C2 domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0099053 activating signal cointegrator 1 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040174 Alkbh3 / Q8K1E6 / Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 / Q96Q83* / alkB homolog 3, alpha-ketoglutaratedependent dioxygenase*  / complex
 ENSMUSG00000020412 Ascc2 / Q91WR3 / Activating signal cointegrator 1 complex subunit 2 / Q9H1I8*  / complex
 ENSMUSG00000044475 Ascc1 / Q9D8Z1 / Activating signal cointegrator 1 complex subunit 1 / Q8N9N2*  / complex






 

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