ENSG00000112249


Homo sapiens

Features
Gene ID: ENSG00000112249
  
Biological name :ASCC3
  
Synonyms : activating signal cointegrator 1 complex subunit 3 / ASCC3 / Q8N3C0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q16.3
Gene start: 100508194
Gene end: 100881372
  
Corresponding Affymetrix probe sets: 212815_at (Human Genome U133 Plus 2.0 Array)   231269_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000320252
Ensembl peptide - ENSP00000358139
Ensembl peptide - ENSP00000358159
Ensembl peptide - ENSP00000430769
Ensembl peptide - ENSP00000320777
NCBI entrez gene - 10973     See in Manteia.
OMIM - 614217
RefSeq - XM_017010206
RefSeq - NM_006828
RefSeq - NM_022091
RefSeq - XM_011535394
RefSeq - XM_011535395
RefSeq - XM_011535396
RefSeq - XM_017010205
RefSeq - NM_001284271
RefSeq Peptide - NP_071374
RefSeq Peptide - NP_001271200
RefSeq Peptide - NP_006819
swissprot - J3KNJ4
swissprot - Q8N3C0
swissprot - E5RFZ0
Ensembl - ENSG00000112249
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ascc3ENSMUSG00000038774Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75643 / SNRNP200 / small nuclear ribonucleoprotein U5 subunit 200ENSG0000014402839
POLQ / O75417 / DNA polymerase thetaENSG0000005134113
HELQ / Q8TDG4 / helicase, POLQ likeENSG000001633128
POLN / Q7Z5Q5 / DNA polymerase nuENSG000001309975


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR003593  AAA+ ATPase domain
 IPR004179  Sec63 domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014756  Immunoglobulin E-set
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035892  C2 domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0032508 DNA duplex unwinding IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0099053 activating signal cointegrator 1 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IDA


Pathways (from Reactome)
Pathway description
ALKBH3 mediated reversal of alkylation damage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138303 ASCC1 / Q8N9N2 / activating signal cointegrator 1 complex subunit 1  / complex
 ENSG00000166199 ALKBH3 / Q96Q83 / alkB homolog 3, alpha-ketoglutaratedependent dioxygenase  / complex
 ENSG00000100325 ASCC2 / Q9H1I8 / activating signal cointegrator 1 complex subunit 2  / complex






 

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