ENSG00000130997


Homo sapiens

Features
Gene ID: ENSG00000130997
  
Biological name :POLN
  
Synonyms : DNA polymerase nu / POLN / Q7Z5Q5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p16.3
Gene start: 2071918
Gene end: 2242121
  
Corresponding Affymetrix probe sets: 233454_at (Human Genome U133 Plus 2.0 Array)   242804_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426401
Ensembl peptide - ENSP00000435506
Ensembl peptide - ENSP00000372316
NCBI entrez gene - 353497     See in Manteia.
OMIM - 610887
RefSeq - NM_181808
RefSeq Peptide - NP_861524
swissprot - H0YA88
swissprot - Q7Z5Q5
Ensembl - ENSG00000130997
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polnENSDARG00000103961Danio rerio
 POLNENSGALG00000015692Gallus gallus
 PolnENSMUSG00000045102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POLQ / O75417 / DNA polymerase thetaENSG0000005134129
ASCC3 / Q8N3C0 / activating signal cointegrator 1 complex subunit 3ENSG0000011224912
O75643 / SNRNP200 / small nuclear ribonucleoprotein U5 subunit 200ENSG0000014402810
HELQ / Q8TDG4 / helicase, POLQ likeENSG000001633126


Protein motifs (from Interpro)
Interpro ID Name
 IPR001098  DNA-directed DNA polymerase, family A, palm domain
 IPR002298  DNA polymerase A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0019985 translesion synthesis IMP
 biological_processGO:0036297 interstrand cross-link repair IMP
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0030332 cyclin binding IPI


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000144554 FANCD2 / Q9BXW9 / Fanconi anemia complementation group D2  / reaction / complex
 ENSG00000140525 FANCI / Q9NVI1 / Fanconi anemia complementation group I  / reaction / complex






 

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