ENSG00000051341


Homo sapiens

Features
Gene ID: ENSG00000051341
  
Biological name :POLQ
  
Synonyms : DNA polymerase theta / O75417 / POLQ
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q13.33
Gene start: 121431427
Gene end: 121546641
  
Corresponding Affymetrix probe sets: 207746_at (Human Genome U133 Plus 2.0 Array)   219510_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481120
Ensembl peptide - ENSP00000264233
NCBI entrez gene - 10721     See in Manteia.
OMIM - 604419
RefSeq - XM_017005565
RefSeq - NM_199420
RefSeq - XM_011512347
RefSeq - XM_011512348
RefSeq - XM_011512352
RefSeq - XM_011512343
RefSeq Peptide - NP_955452
swissprot - O75417
swissprot - A0A087WXL3
Ensembl - ENSG00000051341
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polqENSDARG00000044622Danio rerio
 POLQENSGALG00000014924Gallus gallus
 PolqENSMUSG00000034206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HELQ / Q8TDG4 / helicase, POLQ likeENSG0000016331211
O75643 / SNRNP200 / small nuclear ribonucleoprotein U5 subunit 200ENSG0000014402811
ASCC3 / Q8N3C0 / activating signal cointegrator 1 complex subunit 3ENSG0000011224911
POLN / Q7Z5Q5 / DNA polymerase nuENSG0000013099710


Protein motifs (from Interpro)
Interpro ID Name
 IPR001098  DNA-directed DNA polymerase, family A, palm domain
 IPR001650  Helicase, C-terminal
 IPR002298  DNA polymerase A
 IPR011545  DEAD/DEAH box helicase domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR019760  DNA-directed DNA polymerase, family A, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IEA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006284 base-excision repair IDA
 biological_processGO:0006302 double-strand break repair IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0097681 double-strand break repair via alternative nonhomologous end joining IDA
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003684 damaged DNA binding TAS
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity IDA
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity IDA


Pathways (from Reactome)
Pathway description
HDR through MMEJ (alt-NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000168496 FEN1 / P39748 / flap structure-specific endonuclease 1  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000051341 POLQ / O75417 / DNA polymerase theta  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr