ENSMUSG00000045102


Mus musculus

Features
Gene ID: ENSMUSG00000045102
  
Biological name :Poln
  
Synonyms : DNA polymerase N / Poln
  
Possible biological names infered from orthology : DNA polymerase nu / Q7Z5Q5
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B2
Gene start: 34007179
Gene end: 34169448
  
Corresponding Affymetrix probe sets: 1446271_at (Mouse Genome 430 2.0 Array)   1446582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036110
Ensembl peptide - ENSMUSP00000144578
Ensembl peptide - ENSMUSP00000143793
NCBI entrez gene - 272158     See in Manteia.
MGI - MGI:2675617
RefSeq - NM_001289803
RefSeq - NM_181857
RefSeq - NM_001289804
RefSeq Peptide - NP_862905
RefSeq Peptide - NP_001276732
RefSeq Peptide - NP_001276733
swissprot - A0A0R4J0E3
swissprot - A0A0J9YTQ3
swissprot - A0A0J9YVA9
Ensembl - ENSMUSG00000045102
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polnENSDARG00000103961Danio rerio
 POLNENSGALG00000015692Gallus gallus
 POLNENSG00000130997Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*ENSMUSG0000003420628
Ascc3 / E9PZJ8 / Activating signal cointegrator 1 complex subunit 3 / Q8N3C0*ENSMUSG0000003877412
Q6P4T2 / Snrnp200 / U5 small nuclear ribonucleoprotein 200 kDa helicase / O75643* / small nuclear ribonucleoprotein U5 subunit 200*ENSMUSG0000000366011
Helq / Q2VPA6 / Helicase POLQ-like / Q8TDG4*ENSMUSG000000352666


Protein motifs (from Interpro)
Interpro ID Name
 IPR001098  DNA-directed DNA polymerase, family A, palm domain
 IPR002298  DNA polymerase A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IEA
 biological_processGO:0019985 translesion synthesis IEA
 biological_processGO:0036297 interstrand cross-link repair IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0030332 cyclin binding IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrit3tvrm257/Lrit3tvrm257
Genetic Background: B6.Cg-Lrit3tvrm257/Pjn

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Lrit3tvrm257/Lrit3tvrm257
Genetic Background: B6.Cg-Lrit3tvrm257/Pjn

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrit3tvrm257/Lrit3tvrm257
Genetic Background: B6.Cg-Lrit3tvrm257/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039187 Fanci / Q8K368 / Fanconi anemia group I protein homolog / Q9NVI1* / Fanconi anemia complementation group I*  / reaction / complex
 ENSMUSG00000034023 Fancd2 / Q80V62 / Fanconi anemia group D2 protein homolog / Q9BXW9* / Fanconi anemia complementation group D2*  / reaction / complex






 

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