ENSMUSG00000039187


Mus musculus

Features
Gene ID: ENSMUSG00000039187
  
Biological name :Fanci
  
Synonyms : Fanci / Fanconi anemia group I protein homolog / Q8K368
  
Possible biological names infered from orthology : Fanconi anemia complementation group I / Q9NVI1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D2
Gene start: 79391929
Gene end: 79450264
  
Corresponding Affymetrix probe sets: 10554281 (MoGene1.0st)   1425941_a_at (Mouse Genome 430 2.0 Array)   1427953_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117992
Ensembl peptide - ENSMUSP00000146293
Ensembl peptide - ENSMUSP00000146237
Ensembl peptide - ENSMUSP00000122113
Ensembl peptide - ENSMUSP00000044931
Ensembl peptide - ENSMUSP00000114122
Ensembl peptide - ENSMUSP00000114513
NCBI entrez gene - 208836     See in Manteia.
MGI - MGI:2384790
RefSeq - XM_017322082
RefSeq - NM_145946
RefSeq - XM_006540738
RefSeq - XM_011250833
RefSeq Peptide - NP_666058
swissprot - D3YVC7
swissprot - A0A0U1RQ89
swissprot - A0A0U1RQ41
swissprot - F2Z414
swissprot - F7ALG5
swissprot - Q8K368
Ensembl - ENSMUSG00000039187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fanciENSDARG00000026224Danio rerio
 FANCIENSGALG00000006658Gallus gallus
 FANCIENSG00000140525Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026015  F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily
 IPR026171  Fanconi anemia group I protein
 IPR029305  FANCI solenoid 1 cap
 IPR029308  FANCI solenoid 1 domain
 IPR029310  FANCI helical domain 1
 IPR029312  FANCI helical domain 2
 IPR029313  FANCI solenoid 3 domain
 IPR029314  FANCI solenoid 4 domain
 IPR029315  FANCI solenoid 2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IBA
 biological_processGO:0031398 positive regulation of protein ubiquitination ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex ISS
 molecular_functionGO:0070182 DNA polymerase binding IBA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026429 Ube2t / Q9CQ37 / ubiquitin-conjugating enzyme E2T / Q9NPD8*  / reaction / complex
 ENSMUSG00000028560 Usp1 / Q8BJQ2 / ubiquitin specific peptidase 1 / O94782*  / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000034023 Fancd2 / Q80V62 / Fanconi anemia group D2 protein homolog / Q9BXW9* / Fanconi anemia complementation group D2*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000045102 Poln / DNA polymerase N / Q7Z5Q5* / DNA polymerase nu*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000032512 Wdr48 / Q8BH57 / WD repeat domain 48 / Q8TAF3*  / reaction






 

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