ENSMUSG00000034023


Mus musculus

Features
Gene ID: ENSMUSG00000034023
  
Biological name :Fancd2
  
Synonyms : Fancd2 / Fanconi anemia group D2 protein homolog / Q80V62
  
Possible biological names infered from orthology : Fanconi anemia complementation group D2 / Q9BXW9
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 113531682
Gene end: 113597017
  
Corresponding Affymetrix probe sets: 10540738 (MoGene1.0st)   1430916_at (Mouse Genome 430 2.0 Array)   1438339_at (Mouse Genome 430 2.0 Array)   1439091_at (Mouse Genome 430 2.0 Array)   1442092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122091
Ensembl peptide - ENSMUSP00000145220
Ensembl peptide - ENSMUSP00000144928
Ensembl peptide - ENSMUSP00000045667
NCBI entrez gene - 211651     See in Manteia.
MGI - MGI:2448480
RefSeq - XM_017321491
RefSeq - XM_006505854
RefSeq - XM_017321490
RefSeq - XM_006505857
RefSeq - NM_001033244
RefSeq Peptide - NP_001334279
RefSeq Peptide - NP_001028416
swissprot - Q80V62
swissprot - B2RSU4
swissprot - A0A0N4SV29
swissprot - F7CAP1
swissprot - A0A0N4SVS0
Ensembl - ENSMUSG00000034023
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fancd2ENSDARG00000053574Danio rerio
 FANCD2ENSGALG00000003720Gallus gallus
 FANCD2ENSG00000144554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR029448  Fanconi anaemia protein FANCD2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0010332 response to gamma radiation ISO
 biological_processGO:0034599 cellular response to oxidative stress IGI
 biological_processGO:0045589 regulation of regulatory T cell differentiation IMP
 biological_processGO:0048854 brain morphogenesis IGI
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IGI
 biological_processGO:2000348 regulation of CD40 signaling pathway IMP
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0070182 DNA polymerase binding IBA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Mirc14tm1.1Czc/Mirc14tm1.1Czc,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2+,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Brip1Gt(RRI409)Byg/Brip1Gt(RRI409)Byg,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Dclre1atm1Remo/Dclre1atm1Remo,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mirc14tm1.1Czc/Mirc14tm1.1Czc,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mirc14tm1.1Czc/Mirc14tm1.1Czc,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2+,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Brip1Gt(RRI409)Byg/Brip1Gt(RRI409)Byg,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex,Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004134 abnormal chest morphology "malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex,Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1atm1Remo/Dclre1atm1Remo,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex,Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1atm1Remo/Dclre1atm1Remo,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

Allelic Composition: Fan1tm1.1Jrou/Fan1tm1.1Jrou,Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1atm1Remo/Dclre1atm1Remo,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dclre1atm1Remo/Dclre1atm1Remo,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Aldh2tm1a(EUCOMM)Wtsi/Aldh2tm1a(EUCOMM)Wtsi,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

 MP:0014040 increased cellular sensitivity to DNA damaging agents "greater incidence of cell death following exposure to agents that cause DNA damage" [MGI:csmith]
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Allelic Composition: Brip1Gt(RRI409)Byg/Brip1Gt(RRI409)Byg,Fancd2tm1Hou/Fancd2tm1Hou
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026429 Ube2t / Q9CQ37 / ubiquitin-conjugating enzyme E2T / Q9NPD8*  / reaction / complex
 ENSMUSG00000028560 Usp1 / Q8BJQ2 / ubiquitin specific peptidase 1 / O94782*  / reaction
 ENSMUSG00000039187 Fanci / Q8K368 / Fanconi anemia group I protein homolog / Q9NVI1* / Fanconi anemia complementation group I*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000045102 Poln / DNA polymerase N / Q7Z5Q5* / DNA polymerase nu*  / reaction / complex
 ENSMUSG00000032512 Wdr48 / Q8BH57 / WD repeat domain 48 / Q8TAF3*  / reaction






 

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