ENSMUSG00000028560


Mus musculus

Features
Gene ID: ENSMUSG00000028560
  
Biological name :Usp1
  
Synonyms : Q8BJQ2 / ubiquitin specific peptidase 1 / Usp1
  
Possible biological names infered from orthology : O94782
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 98923810
Gene end: 98935543
  
Corresponding Affymetrix probe sets: 10506118 (MoGene1.0st)   1423674_at (Mouse Genome 430 2.0 Array)   1423675_at (Mouse Genome 430 2.0 Array)   1451080_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135496
Ensembl peptide - ENSMUSP00000030289
Ensembl peptide - ENSMUSP00000088917
Ensembl peptide - ENSMUSP00000130307
NCBI entrez gene - 230484     See in Manteia.
MGI - MGI:2385198
RefSeq - NM_146144
RefSeq - XM_006502939
RefSeq - NM_001301414
RefSeq Peptide - NP_001288343
RefSeq Peptide - NP_666256
swissprot - E9Q778
swissprot - Q8BJQ2
swissprot - H3BKR6
Ensembl - ENSMUSG00000028560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp1ENSDARG00000056414Danio rerio
 USP1ENSGALG00000010957Gallus gallus
 USP1ENSG00000162607Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR033815  Ubiquitin specific peptidase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006282 regulation of DNA repair ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV ISO
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0035520 monoubiquitinated protein deubiquitination ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+,Igs12tm1Zhu/Igs12tm1Zhu,Ptprca/Ptprcb,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+,Igs12tm1Zhu/Igs12tm1Zhu,Ptprca/Ptprcb,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+,Igs12tm1Zhu/Igs12tm1Zhu,Ptprca/Ptprcb,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex,Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex,Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex,Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+,Igs12tm1Zhu/Igs12tm1Zhu,Ptprca/Ptprcb,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+,Igs12tm1Zhu/Igs12tm1Zhu,Ptprca/Ptprcb,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J

 MP:0010924 abnormal osteoid morphology "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+,Igs12tm1Zhu/Igs12tm1Zhu,Ptprca/Ptprcb,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Oca2p-9J/Oca2p-9J
Genetic Background: B10.A-H2h2/(2R)SgSnJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039187 Fanci / Q8K368 / Fanconi anemia group I protein homolog / Q9NVI1* / Fanconi anemia complementation group I*  / reaction
 ENSMUSG00000034023 Fancd2 / Q80V62 / Fanconi anemia group D2 protein homolog / Q9BXW9* / Fanconi anemia complementation group D2*  / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000032512 Wdr48 / Q8BH57 / WD repeat domain 48 / Q8TAF3*  / complex






 

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