ENSG00000162607


Homo sapiens

Features
Gene ID: ENSG00000162607
  
Biological name :USP1
  
Synonyms : O94782 / ubiquitin specific peptidase 1 / USP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.3
Gene start: 62436297
Gene end: 62451804
  
Corresponding Affymetrix probe sets: 202412_s_at (Human Genome U133 Plus 2.0 Array)   202413_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360188
Ensembl peptide - ENSP00000403662
Ensembl peptide - ENSP00000387986
Ensembl peptide - ENSP00000343526
NCBI entrez gene - 7398     See in Manteia.
OMIM - 603478
RefSeq - NM_001017415
RefSeq - NM_001017416
RefSeq - NM_003368
RefSeq Peptide - NP_001017416
RefSeq Peptide - NP_003359
RefSeq Peptide - NP_001017415
swissprot - O94782
swissprot - C9JC88
swissprot - C9JWX4
Ensembl - ENSG00000162607
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp1ENSDARG00000056414Danio rerio
 USP1ENSGALG00000010957Gallus gallus
 Usp1ENSMUSG00000028560Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR033815  Ubiquitin specific peptidase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006282 regulation of DNA repair IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV IDA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IMP
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity EXP
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IDA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000144554 FANCD2 / Q9BXW9 / Fanconi anemia complementation group D2  / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000140525 FANCI / Q9NVI1 / Fanconi anemia complementation group I  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000114742 WDR48 / Q8TAF3 / WD repeat domain 48  / complex






 

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