ENSG00000166199


Homo sapiens

Features
Gene ID: ENSG00000166199
  
Biological name :ALKBH3
  
Synonyms : ALKBH3 / alkB homolog 3, alpha-ketoglutaratedependent dioxygenase / Q96Q83
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 43880811
Gene end: 43920266
  
Corresponding Affymetrix probe sets: 226127_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432259
Ensembl peptide - ENSP00000436788
Ensembl peptide - ENSP00000435848
Ensembl peptide - ENSP00000434832
Ensembl peptide - ENSP00000434229
Ensembl peptide - ENSP00000433614
Ensembl peptide - ENSP00000302232
NCBI entrez gene - 221120     See in Manteia.
OMIM - 610603
RefSeq - NM_139178
RefSeq Peptide - NP_631917
swissprot - E9PN35
swissprot - H0YDH4
swissprot - E9PSA5
swissprot - Q96Q83
swissprot - E9PRJ2
swissprot - E9PRD0
Ensembl - ENSG00000166199
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh3ENSDARG00000045606Danio rerio
 ALKBH3ENSGALG00000041309Gallus gallus
 Alkbh3ENSMUSG00000040174Mus musculus
 Gm27027ENSMUSG00000098004Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALKBH2 / Q6NS38 / alkB homolog 2, alpha-ketoglutarate dependent dioxygenaseENSG0000018904628


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR032854  Alkylated DNA repair protein alkB homologue 3
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0035552 oxidative single-stranded DNA demethylation IEA
 biological_processGO:0035553 oxidative single-stranded RNA demethylation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008198 ferrous iron binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0043734 DNA-N1-methyladenine dioxygenase activity IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:1990930 RNA N1-methyladenosine dioxygenase activity IDA


Pathways (from Reactome)
Pathway description
ALKBH3 mediated reversal of alkylation damage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100325 ASCC2 / Q9H1I8 / activating signal cointegrator 1 complex subunit 2  / complex
 ENSG00000138303 ASCC1 / Q8N9N2 / activating signal cointegrator 1 complex subunit 1  / complex
 ENSG00000112249 ASCC3 / Q8N3C0 / activating signal cointegrator 1 complex subunit 3  / complex






 

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