ENSMUSG00000040174


Mus musculus

Features
Gene ID: ENSMUSG00000040174
  
Biological name :Alkbh3
  
Synonyms : Alkbh3 / Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 / Q8K1E6
  
Possible biological names infered from orthology : alkB homolog 3, alpha-ketoglutaratedependent dioxygenase / Q96Q83
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E1
Gene start: 93980550
Gene end: 94010807
  
Corresponding Affymetrix probe sets: 10485282 (MoGene1.0st)   1428889_at (Mouse Genome 430 2.0 Array)   1444184_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106871
Ensembl peptide - ENSMUSP00000122043
Ensembl peptide - ENSMUSP00000038721
NCBI entrez gene - 69113     See in Manteia.
MGI - MGI:1916363
RefSeq - XM_006500123
RefSeq - XM_006500125
RefSeq - XM_006500126
RefSeq - NM_026944
RefSeq Peptide - NP_081220
swissprot - Q8K1E6
swissprot - A2AKV6
swissprot - A2AKV7
Ensembl - ENSMUSG00000040174
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh3ENSDARG00000045606Danio rerio
 ALKBH3ENSGALG00000041309Gallus gallus
 ALKBH3ENSG00000166199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alkbh2 / Q6P6J4 / DNA oxidative demethylase ALKBH2 / Q6NS38* / alkB homolog 2, alpha-ketoglutarate dependent dioxygenase*ENSMUSG0000004433928
Gm27027 / ALKBH3* / Q96Q83* / alkB homolog 3, alpha-ketoglutaratedependent dioxygenase*ENSMUSG0000009800423


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR032854  Alkylated DNA repair protein alkB homologue 3
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006307 DNA dealkylation involved in DNA repair ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0035552 oxidative single-stranded DNA demethylation ISS
 biological_processGO:0035553 oxidative single-stranded RNA demethylation ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0008198 ferrous iron binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
 molecular_functionGO:0043734 DNA-N1-methyladenine dioxygenase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051747 cytosine C-5 DNA demethylase activity IDA
 molecular_functionGO:1990930 RNA N1-methyladenosine dioxygenase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alkbh2tm1Klng/Alkbh2tm1Klng,Alkbh3tm1Klng/Alkbh3tm1Klng
Genetic Background: involves: C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Alkbh2tm1Klng/Alkbh2tm1Klng,Alkbh3tm1Klng/Alkbh3tm1Klng
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038774 Ascc3 / E9PZJ8 / Activating signal cointegrator 1 complex subunit 3 / Q8N3C0*  / complex
 ENSMUSG00000044475 Ascc1 / Q9D8Z1 / Activating signal cointegrator 1 complex subunit 1 / Q8N9N2*  / complex
 ENSMUSG00000020412 Ascc2 / Q91WR3 / Activating signal cointegrator 1 complex subunit 2 / Q9H1I8*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr