ENSMUSG00000044339


Mus musculus

Features
Gene ID: ENSMUSG00000044339
  
Biological name :Alkbh2
  
Synonyms : Alkbh2 / DNA oxidative demethylase ALKBH2 / Q6P6J4
  
Possible biological names infered from orthology : alkB homolog 2, alpha-ketoglutarate dependent dioxygenase / Q6NS38
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 114123926
Gene end: 114128218
  
Corresponding Affymetrix probe sets: 10532802 (MoGene1.0st)   1455673_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056043
Ensembl peptide - ENSMUSP00000107898
Ensembl peptide - ENSMUSP00000142877
NCBI entrez gene - 231642     See in Manteia.
MGI - MGI:2141032
RefSeq - XM_006530292
RefSeq - NM_175016
RefSeq - XM_006530289
RefSeq - XM_006530290
RefSeq - XM_006530291
RefSeq Peptide - NP_778181
swissprot - Q6P6J4
swissprot - A0A0G2JER8
Ensembl - ENSMUSG00000044339
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh2ENSDARG00000059856Danio rerio
 ALKBH2ENSGALG00000035152Gallus gallus
 ALKBH2ENSG00000189046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alkbh3 / Q8K1E6 / Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 / Q96Q83* / alkB homolog 3, alpha-ketoglutaratedependent dioxygenase*ENSMUSG0000004017433
Gm27027 / ALKBH3* / Q96Q83* / alkB homolog 3, alpha-ketoglutaratedependent dioxygenase*ENSMUSG0000009800414


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0035511 oxidative DNA demethylation ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 molecular_functionGO:0008198 ferrous iron binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
 molecular_functionGO:0043734 DNA-N1-methyladenine dioxygenase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051747 cytosine C-5 DNA demethylase activity ISO
 molecular_functionGO:0103053 1-ethyladenine demethylase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Alkbh2tm1Klng/Alkbh2tm1Klng,Alkbh3tm1Klng/Alkbh3tm1Klng
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr