ENSG00000189046


Homo sapiens

Features
Gene ID: ENSG00000189046
  
Biological name :ALKBH2
  
Synonyms : ALKBH2 / alkB homolog 2, alpha-ketoglutarate dependent dioxygenase / Q6NS38
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.11
Gene start: 109088188
Gene end: 109093631
  
Corresponding Affymetrix probe sets: 225625_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478765
Ensembl peptide - ENSP00000444103
Ensembl peptide - ENSP00000474702
Ensembl peptide - ENSP00000343021
Ensembl peptide - ENSP00000398181
Ensembl peptide - ENSP00000399820
Ensembl peptide - ENSP00000443042
NCBI entrez gene - 121642     See in Manteia.
OMIM - 610602
RefSeq - XM_005253836
RefSeq - NM_001001655
RefSeq - NM_001145374
RefSeq - NM_001145375
RefSeq - NM_001205179
RefSeq - NM_001205180
RefSeq - XM_005253835
RefSeq Peptide - NP_001001655
RefSeq Peptide - NP_001138846
RefSeq Peptide - NP_001138847
RefSeq Peptide - NP_001192108
RefSeq Peptide - NP_001192109
swissprot - F5GZZ0
swissprot - Q6NS38
swissprot - F5H5X2
swissprot - S4R3T5
Ensembl - ENSG00000189046
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh2ENSDARG00000059856Danio rerio
 ALKBH2ENSGALG00000035152Gallus gallus
 Alkbh2ENSMUSG00000044339Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALKBH3 / Q96Q83 / alkB homolog 3, alpha-ketoglutaratedependent dioxygenaseENSG0000016619930


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0035511 oxidative DNA demethylation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070989 oxidative demethylation TAS
 biological_processGO:0080111 DNA demethylation TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 molecular_functionGO:0008198 ferrous iron binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0043734 DNA-N1-methyladenine dioxygenase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051747 cytosine C-5 DNA demethylase activity TAS
 molecular_functionGO:0103053 1-ethyladenine demethylase activity IEA


Pathways (from Reactome)
Pathway description
ALKBH2 mediated reversal of alkylation damage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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