ENSMUSG00000020412


Mus musculus

Features
Gene ID: ENSMUSG00000020412
  
Biological name :Ascc2
  
Synonyms : Activating signal cointegrator 1 complex subunit 2 / Ascc2 / Q91WR3
  
Possible biological names infered from orthology : Q9H1I8
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 4637747
Gene end: 4685699
  
Corresponding Affymetrix probe sets: 10373924 (MoGene1.0st)   1418348_a_at (Mouse Genome 430 2.0 Array)   1427156_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063272
Ensembl peptide - ENSMUSP00000105556
NCBI entrez gene - 75452     See in Manteia.
MGI - MGI:1922702
RefSeq - XM_006514874
RefSeq - NM_029291
RefSeq Peptide - NP_083567
swissprot - Q91WR3
Ensembl - ENSMUSG00000020412
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ascc2ENSDARG00000013058Danio rerio
 ASCC2ENSGALG00000008059Gallus gallus
 ASCC2ENSG00000100325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003892  Ubiquitin system component Cue
 IPR009060  UBA-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0099053 activating signal cointegrator 1 complex ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038774 Ascc3 / E9PZJ8 / Activating signal cointegrator 1 complex subunit 3 / Q8N3C0*  / complex
 ENSMUSG00000044475 Ascc1 / Q9D8Z1 / Activating signal cointegrator 1 complex subunit 1 / Q8N9N2*  / complex
 ENSMUSG00000040174 Alkbh3 / Q8K1E6 / Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 / Q96Q83* / alkB homolog 3, alpha-ketoglutaratedependent dioxygenase*  / complex






 

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