ENSMUSG00000035367


Mus musculus

Features
Gene ID: ENSMUSG00000035367
  
Biological name :Rmi1
  
Synonyms : Q9D4G9 / RecQ-mediated genome instability protein 1 / Rmi1
  
Possible biological names infered from orthology : Q9H9A7 / RecQ mediated genome instability 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 58402248
Gene end: 58411148
  
Corresponding Affymetrix probe sets: 10405628 (MoGene1.0st)   10608422 (MoGene1.0st)   1428625_a_at (Mouse Genome 430 2.0 Array)   1430805_s_at (Mouse Genome 430 2.0 Array)   1438573_at (Mouse Genome 430 2.0 Array)   1439248_at (Mouse Genome 430 2.0 Array)   1456696_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041035
Ensembl peptide - ENSMUSP00000153050
Ensembl peptide - ENSMUSP00000153621
Ensembl peptide - ENSMUSP00000153675
NCBI entrez gene - 74386     See in Manteia.
MGI - MGI:1921636
RefSeq - XM_006517420
RefSeq - NM_001168248
RefSeq - NM_028904
RefSeq Peptide - NP_083180
RefSeq Peptide - NP_001161720
swissprot - Q9D4G9
Ensembl - ENSMUSG00000035367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rmi1ENSDARG00000041376Danio rerio
 RMI1ENSGALG00000012592Gallus gallus
 RMI1ENSG00000178966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tdrd3 / Q91W18 / Tudor domain-containing protein 3 / Q9H7E2* / tudor domain containing 3*ENSMUSG0000002201917


Protein motifs (from Interpro)
Interpro ID Name
 IPR013894  RecQ mediated genome instability protein, N-terminal
 IPR032199  Recq-mediated genome instability protein 1, C-terminal OB-fold domain
 IPR033472  RecQ mediated genome instability protein, DUF1767


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0002023 reduction of food intake in response to dietary excess IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042593 glucose homeostasis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ay/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

Allelic Composition: a/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Ay/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ay/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

Allelic Composition: a/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ay/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

Allelic Composition: a/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ay/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

Allelic Composition: a/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: a/a,Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic Background: involves: C57BL/6 * KK

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / reaction / complex
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / complex
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000041974 Spidr / Q8BGX7 / DNA repair-scaffolding protein / Q14159* / scaffolding protein involved in DNA repair*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex






 

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