Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd
MP:0000313	abnormal cell death	"anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fbln5^tm1Krc/Fbln5^tm1Krc Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000351	increased cell proliferation	"greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn Genetic Background: involves: 129P2/OlaHsd
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000400	abnormal awl hair	"anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000423	delayed hair regrowth	"slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0000468	abnormal esophageal epithelium morphology	"malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0000471	abnormal stomach epithelium morphology	"malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: B6.129-Brca1^tm2Arge Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1
MP:0000621	salivary adenocarcinoma	"malignant neoplasm of the secreting cells of the salivary gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash,Trp53^tm1Brd/Trp53⁺,Tg(LGB-cre)74Acl/0 Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash,Tg(LGB-cre)74Acl/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000627	abnormal mammary gland morphology	"malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]	Show Allelic Composition: Rac1^tm1Brak/Rac1^tm1Brak,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0000628	abnormal mammary gland development	"aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^tm1.1Rck/Lepr^tm1.1Rck Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash,Trp53^tm1Brd/Trp53⁺,Tg(LGB-cre)74Acl/0 Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000630	mammary gland hyperplasia	"increased size of mammary gland due to increased cell number" [J:63229]	Show Allelic Composition: Rac1^tm1Brak/Rac1^tm1Brak,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000662	abnormal branching of the mammary ductal tree	"anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^tm1.1Rck/Lepr^tm1.1Rck Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000709	enlarged thymus	"increased size of thymus" [J:50053]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000786	abnormal neuroepithelial layer differentiation	"malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Gadd45a^tm1Ajf/Gadd45a^tm1Ajf Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6 Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Bhk/Brca1^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Hoxd13^tm1Mrc/Hoxd13⁺ Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn Genetic Background: involves: 129P2/OlaHsd
MP:0001138	abnormal cervical squamous epithelium	"malformation of the scaly epithelial layer of the cervix" [MGI:tc, J:54637]	Show Allelic Composition: Rac1^tm1Brak/Rac1^tm1Brak,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm3.1Thl/Brca1^tm3.1Thl Genetic Background: involves: 129 * C57BL/6
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: B6.129-Brca1^tm2Arge Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1 Allelic Composition: Brca1^tm3.1Thl/Brca1^tm3.1Thl Genetic Background: involves: 129 * C57BL/6
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Glra1^tm1Rah/Glra1^tm1Rah Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm2Cxd/Brca1⁺,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001244	thin dermal layer	"reduced thickness of the dermis" [J:65030]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Hoxd13^tm1Mrc/Hoxd13⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm3.1Thl/Brca1^tm3.1Thl Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Brca1^tm1Bhk/Brca1⁺ Genetic Background: C.129P2-Brca1^tm1Bhk
MP:0001272	increased metastatic potential		Show Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Pkm^tm1.1Mgvh/Pkm^tm1.1Mgvh,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53^tm1Brn/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0001658	increased mortality induced by gamma-irradiation	"greater sensitivity to doses of ionizing radiation" [J:51834]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001684	abnormal axial mesoderm	"malformed middle primary germ layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:51834]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6)
MP:0001689	incomplete somite formation	"arrest of differentiation or patterning of the somites" [J:62882]	Show Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd
MP:0001693	failure of primitive streak formation	"inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0001694	failure to form egg cylinders	"inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]	Show Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6) Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0001710	absent amniotic folds	"failure of amnion to form involutions" [J:40594]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0001714	absent trophoblast cells	"missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0001718	abnormal yolk sac	"malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak,Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0001726	abnormal allantois	"malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak,Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: B6.129-Brca1^tm2Arge Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1
MP:0001792	impaired wound healing	"reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0001883	mammary adenocarcinoma	"higher than normal incidence of malignant tumors of the mammary gland" [J:62919]	Show Allelic Composition: Lepr^tm1.1Rck/Lepr^tm1.1Rck Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm1Arge/Brca1^tm1Thl,Wap^tm1(cre)Arge/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J Allelic Composition: Brca1^tm1Thl/Brca1^tm1Thl,Wap^tm1(cre)Arge/0 Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Bard1^tm2Thl/Bard1^tm2Thl,Brca1^tm1Thl/Brca1^tm1Thl,Wap^tm1(cre)Arge/0 Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Chek2^tm1Mak/Chek2^tm1Mak,Tg(Wap-cre)11738Mam/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Trp53^tm1Brd/Trp53⁺,Tg(Wap-cre)11738Mam/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0001884	mammary alveolar hyperplasia		Show Allelic Composition: Pglyrp1^tm1Rdz/Pglyrp1^tm1Rdz,Pglyrp2^tm1Rdz/Pglyrp2^tm1Rdz Genetic Background: C.129S-Pglyrp1^tm1Rdz Pglyrp2^tm1Rdz Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
MP:0001885	mammary ductal hyperplasia		Show Allelic Composition: Rac1^tm1Brak/Rac1^tm1Brak,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: B6.129-Brca1^tm2Arge Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1 Allelic Composition: Brca1^tm2.1Thl/Brca1^tm2.1Thl Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Brca1^tm3.1Thl/Brca1^tm3.1Thl Genetic Background: involves: 129 * C57BL/6
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0002007	increased sensitivity to gamma-irradiation	"increased incidence of cell death following high levels of gamma-irradiation" [J:51834]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6) Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002009	preneoplasia	"state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]	Show Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
MP:0002014	papilloma	"benign epithelial tumor" [J:47225]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002016	ovarian cysts	"cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Map1b^tm1Noh/Map1b^tm1Noh,Map2^tm1Noh/Map2^tm1Noh Genetic Background: involves: C57BL/6
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: B6.129-Brca1^tm2Arge Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1 Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Trp53^tm1Brd/Trp53^tm1Brd,Tg(Wap-cre)11738Mam/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL Allelic Composition: Brca1^tm2Cxd/Brca1⁺,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm2.1Thl/Brca1^tm2.1Thl Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129 * C57BL/6
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Chek2^tm1Mak/Chek2^tm1Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002038	carcinoma	"malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53^tm1Brn/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gata4^tm1Jml/Gata4⁺,Gata5^tm1Eem/Gata5^tm1Eem Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gata4^tm1Jml/Gata4⁺,Gata5^tm1Eem/Gata5^tm1Eem Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Arge/Brca1^tm1Arge,Brca2^tm1Arge/Brca2^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Bard1^tm1Thl/Bard1^tm1Thl,Brca1^tm1Arge/Brca1^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Pkm^tm1.1Mgvh/Pkm^tm1.1Mgvh,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6) Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Bard1^tm1Thl/Bard1^tm1Thl,Brca1^tm1Arge/Brca1^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6) Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Brca1^tm1Arge/Brca1^tm1Arge,Brca2^tm1Arge/Brca2^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Bard1^tm1Thl/Bard1^tm1Thl,Brca1^tm1Arge/Brca1^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd
MP:0002086	abnormal extraembryonic tissue morphology	"structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0002095	abnormal skin pigmentation	"variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: B6.129-Brca1^tm2Arge Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Bhk/Brca1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Brca1^tm1Mak/Brca1⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Brca1^tm1Whl/Brca1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Brca1^tm1Thl/Brca1^tm1Thl Genetic Background: involves: 129 * C57BL/6J
MP:0002230	abnormal primitive streak formation	"anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6)
MP:0002269	muscular atrophy	"a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0002582	disorganized extraembryonic tissue	"a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0002676	uterine hyperplasia	"increased size of the uterus due to increased cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0003054	spina bifida	"common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm4Cxd/Brca1^tm4Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0003085	abnormal egg cylinder morphology	"anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0003091	abnormal cell migration	"defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac
MP:0003111	abnormal nucleus morphology	"abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm4Cxd/Brca1^tm4Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0003155	abnormal telomere length	"abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0003401	enlarged tail bud	"increased size or area of the primordial region of the embryo that arises to form the tail of the adult" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd
MP:0003448	altered tumor morphology	"changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1.1Jjon,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
MP:0003566	abnormal cell adhesion	"altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac
MP:0003574	abnormal oviduct morphology	"malformation of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53^tm1Brn/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
MP:0003579	ovarian carcinoma		Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53^tm1Brn/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
MP:0003587	ureter obstruction	"any impediment, blockage, or reversal of the normal flow of the urine towards the bladder" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Pglyrp1^tm1Rdz/Pglyrp1^tm1Rdz,Pglyrp2^tm1Rdz/Pglyrp2^tm1Rdz Genetic Background: C.129S-Pglyrp1^tm1Rdz Pglyrp2^tm1Rdz Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Map1b^tm1Noh/Map1b^tm1Noh,Map2^tm1Noh/Map2^tm1Noh Genetic Background: involves: C57BL/6
MP:0003702	abnormal chromosome morphology	"anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0003750	mouth tumor	"presence of abnormal rapidly proliferating cells in the mouth, usually in the form of a distinct mass" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0003795	abnormal bone structure		Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0003890	abnormal embryonic-extraembryonic boundary morphology	"anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Brca1^tm1Arge/Brca1^tm1Arge,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Gadd45a^tm1Ajf/Gadd45a^tm1Ajf Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6 Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas Allelic Composition: Brca1^tm1.1Jjon/Brca1^tm1.1Jjon Genetic Background: involves: C57BL/6J
MP:0003988	disorganized embryonic tissue	"a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]	Show Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004023	abnormal chromosome number	"chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6) Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0004024	aneuploidy	"chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Gadd45a^tm1Ajf/Gadd45a^tm1Ajf Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6 Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0004028	chromosome breakage	"chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Cd19^tm1(cre)Cgn/Cd19⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0004029	spontaneous chromosome breakage	"chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(BCL2)36Wehi/?,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0004045	abnormal cell cycle checkpoint function	"anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0004180	failure of initiation of embryo turning	"failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0004207	squamous cell carcinoma	"a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm2Cxd/Brca1⁺,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0004500	increased incidence of ionizing radiation-induced tumors	"higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0005031	abnormal trophoblast	"malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm3.1Thl/Brca1^tm3.1Thl Genetic Background: involves: 129 * C57BL/6
MP:0005169	abnormal male meiosis	"malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd
MP:0006269	abnormal mammary gland growth during pregnancy	"anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^tm1.1Rck/Lepr^tm1.1Rck Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB
MP:0006271	abnormal involution of the mammary gland	"anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^tm1.1Rck/Lepr^tm1.1Rck Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB
MP:0006380	abnormal spermatid morphology	"anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0006387	abnormal T cell number	"deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008000	ovary tumor	"presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53^tm1Brn/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Thl/Brca1^tm2.1Thl Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm1Bhk/Brca1⁺ Genetic Background: C.129P2-Brca1^tm1Bhk
MP:0008019	liver tumor	"presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Pkm^tm1.1Mgvh/Pkm^tm1.1Mgvh,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008108	abnormal small intestinal villus morphology	"any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0008261	arrest of male meiosis	"cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0008280	male germ cell apoptosis	"presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0008866	chromosomal instability	"abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]	Show Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Lck-cre)548Jxm/?,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(BCL2)36Wehi/?,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Chek2^tm1Mak/Chek2^tm1Mak,Tg(Lck-cre)548Jxm/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0009092	endometrium hyperplasia	"overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm4Cxd/Brca1^tm4Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0009503	abnormal mammary gland duct morphology	"any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm4Cxd/Brca1^tm4Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB
MP:0009504	abnormal mammary gland epithelium morphology	"any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm4Cxd/Brca1^tm4Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0009505	abnormal mammary gland lobule morphology	"any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0009508	mammary gland ductal carcinoma	"higher than normal incidence of malignant tumors of the ducts of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm4Cxd/Brca1^tm4Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash,Trp53^tm1Brd/Trp53⁺,Tg(LGB-cre)74Acl/0 Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA
MP:0009566	meiotic nondisjunction	"failure of homologous chromosomes to separate to the cell poles at anaphase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0009583	increased keratinocyte proliferation	"increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm2Cxd/Brca1⁺,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0009687	empty decidua capsularis	"the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA
MP:0009760	abnormal mitotic spindle	"an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]	Show Allelic Composition: Brca1^tm2.1Thl/Brca1^tm2.1Thl Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129
MP:0009828	delayed tumor appearance	"later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm3.1Thl,Trp53^tm3Tyj/Trp53⁺,Wap^tm1(cre)Arge/Wap⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0010173	increased mammary gland epithelium proliferation	"increase in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
MP:0010174	decreased mammary gland epithelium proliferation	"decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Bhk/Brca1⁺ Genetic Background: C.129P2-Brca1^tm1Bhk
MP:0010264	increased hepatoma incidence	"greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0010269	decreased mammary gland tumor incidence	"less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1.1Jjon,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
MP:0010285	decreased skin tumor incidence	"less than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1.1Jjon,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
MP:0010287	increased reproductive system tumor incidence	"greater than the expected number of tumors originating in the reproductive system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0010299	increased mammary gland tumor incidence	"greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lepr^tm1.1Rck/Lepr^tm1.1Rck Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Trp53^tm1Brd/Trp53⁺,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: 129-Brca1^tm2Arge Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129/Sv * C57BL/6J * MF1 Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm4Cxd/Brca1^tm4Cxd Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash,Trp53^tm1Brd/Trp53⁺,Tg(LGB-cre)74Acl/0 Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash,Tg(LGB-cre)74Acl/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Brca1^tm1Brn/Brca1⁺,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Trp53^tm1Brn/Trp53⁺,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak,Tg(Wap-cre)11738Mam/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N Allelic Composition: Brca1^tm1Bhk/Brca1⁺ Genetic Background: C.129P2-Brca1^tm1Bhk Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd,Pkm^tm1.1Mgvh/Pkm^tm1.1Mgvh,Tg(MMTV-cre)4Mam/0,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
MP:0010300	increased skin tumor incidence	"greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm2Cxd/Brca1⁺,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
MP:0010308	decreased tumor latency	"earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Brca1^tm1Brn/Brca1^tm1.1Jjon,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Thl,Trp53^tm3Tyj/Trp53⁺,Wap^tm1(cre)Arge/Wap⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm3Tyj/Trp53⁺,Wap^tm1(cre)Arge/Wap⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Brca1^tm1Thl/Brca1^tm3.1Thl,Kras^tm4Tyj/Kras⁺,Trp53^tm1Thl/Trp53^tm1Thl,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Brca1^tm1Thl/Brca1^tm1Thl,Kras^tm4Tyj/Kras⁺,Trp53^tm1Thl/Trp53^tm1Thl,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Brca1^tm1Thl/Brca1^tm2.1Thl,Kras^tm4Tyj/Kras⁺,Trp53^tm1Thl/Trp53^tm1Thl,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0010343	increased lipoma incidence	"greater than the expected number of a benign neoplasia derived from lipoblasts or lipocytes of white or brown fat, occurring in a specific population in a given time period" [MPATH:417]	Show Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0010639	altered tumor pathology	"any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1.1Jjon,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
MP:0010948	abnormal double-strand DNA break repair	"any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]	Show Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: involves: 129
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Brca1^tm1.1Brn/Brca1^tm1.1Brn Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Gadd45a^tm1Ajf/Gadd45a^tm1Ajf Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Arge/Brca1^tm1Arge,Brca2^tm1Arge/Brca2^tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Brca1^tm1Arge/Brca1^tm1Arge,Tg(Hsp70-1-cre)1Arge/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0011095	complete embryonic lethality between implantation and placentation	"death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd Genetic Background: either: 129S6/SvEvTac-Brca1^tm1Cxd or (involves: 129S6/SvEvBrd * Black Swiss) or (involves: 129S6/SvEvBrd * C57BL/6)
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia Genetic Background: involves: BALB/c * C57BL/6 * CBA Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Brca1^tm1Bhk/Brca1^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak,Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas Allelic Composition: Brca1^tm1.1Jjon/Brca1^tm1.1Jjon Genetic Background: involves: C57BL/6J
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Parp1^tm1Zqw/Parp1^tm1Zqw Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac Allelic Composition: Brca1^tm1Bhk/Brca1^tm1Bhk,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Foxc1^tm1Blh/Foxc1^tm1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Brca1^tm2Arge/Brca1^tm2Arge Genetic Background: B6.129-Brca1^tm2Arge
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm2Cxd,Tg(KRT5-cre)5132Jlj/0,Tg(KRT5-E2F1)2Dgj/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0011186	abnormal visceral endoderm morphology	"any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0011187	abnormal parietal endoderm morphology	"any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]	Show Allelic Composition: Brca1^tm1Mak/Brca1^tm1Mak Genetic Background: either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
MP:0011703	increased fibroblast proliferation	"greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0011704	decreased fibroblast proliferation	"reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Brca1^tm2.1Thl/Brca1^tm2.1Thl Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Brca1^tm3Cxd/Brca1^tm3Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0013184	hemorrhagic ascites	"the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna]	Show Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53^tm1Brn/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
MP:0013504	increased embryonic tissue cell apoptosis	"increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Brca1^tm2.1Cxd/Brca1^tm2.1Cxd,Trp53^tm1Brd/Trp53⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0014082	decreased small intestinal villus height	"decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0014126	increased mammary gland apoptosis	"increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Brca1^tm5.1Cxd/Brca1^tm5.1Cxd Genetic Background: involves: 129S6/SvEvTac * FVB/N

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