ENSMUSG00000044702


Mus musculus

Features
Gene ID: ENSMUSG00000044702
  
Biological name :Palb2
  
Synonyms : Palb2 / Partner and localizer of BRCA2 / Q3U0P1
  
Possible biological names infered from orthology : Q86YC2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F2
Gene start: 122107262
Gene end: 122132985
  
Corresponding Affymetrix probe sets: 10567663 (MoGene1.0st)   1434808_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118059
Ensembl peptide - ENSMUSP00000102077
Ensembl peptide - ENSMUSP00000123041
Ensembl peptide - ENSMUSP00000063514
Ensembl peptide - ENSMUSP00000095675
Ensembl peptide - ENSMUSP00000102076
NCBI entrez gene - 233826     See in Manteia.
MGI - MGI:3040695
RefSeq - XM_011241756
RefSeq - NM_001081238
RefSeq - NM_001289842
RefSeq - NM_001289843
RefSeq - NM_001289844
RefSeq - NM_001289845
RefSeq - XM_011241755
RefSeq Peptide - NP_001276772
RefSeq Peptide - NP_001276773
RefSeq Peptide - NP_001276774
RefSeq Peptide - NP_001074707
RefSeq Peptide - NP_001276771
swissprot - Q3U0P1
swissprot - F6VTV6
swissprot - D6RDD1
swissprot - D3YVU6
Ensembl - ENSMUSG00000044702
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 palb2ENSDARG00000076716Danio rerio
 PALB2ENSGALG00000006078Gallus gallus
 PALB2ENSG00000083093Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR031920  Partner and localiser of BRCA2, WD40 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0048568 embryonic organ development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

Allelic Composition: Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0003750 mouth tumor "presence of abnormal rapidly proliferating cells in the mouth, usually in the form of a distinct mass" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

Allelic Composition: Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex
 ENSMUSG00000018841 O55230 / Rad51d / RAD51 paralog D / O75771*  / reaction
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / reaction
 ENSMUSG00000028933 Xrcc2 / Q9CX47 / X-ray repair complementing defective repair in Chinese hamster cells 2 / O43543* / X-ray repair cross complementing 2*  / reaction
 ENSMUSG00000030346 Rad51ap1 / RAD51-associated protein 1 isoform 2 / Q96B01* / RAD51 associated protein 1*  / reaction / complex
 ENSMUSG00000059060 O35719 / Rad51b / DNA repair 2 / O15315* / RAD51 paralog B*  / reaction
 ENSMUSG00000041147 Brca2 / P97929 / Breast cancer type 2 susceptibility protein homolog / P51587* / BRCA2, DNA repair associated*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr