ENSMUSG00000028933


Mus musculus

Features
Gene ID: ENSMUSG00000028933
  
Biological name :Xrcc2
  
Synonyms : Q9CX47 / X-ray repair complementing defective repair in Chinese hamster cells 2 / Xrcc2
  
Possible biological names infered from orthology : O43543 / X-ray repair cross complementing 2
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 25689812
Gene end: 25705825
  
Corresponding Affymetrix probe sets: 10528790 (MoGene1.0st)   1453950_a_at (Mouse Genome 430 2.0 Array)   1455335_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143032
Ensembl peptide - ENSMUSP00000030773
NCBI entrez gene - 57434     See in Manteia.
MGI - MGI:1927345
RefSeq - NM_020570
RefSeq Peptide - NP_065595
swissprot - A0A0G2JF58
swissprot - Q9CX47
Ensembl - ENSMUSG00000028933
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 XRCC2ENSDARG00000013933Danio rerio
 XRCC2ENSGALG00000026865Gallus gallus
 XRCC2ENSG00000196584Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030547  DNA repair protein XRCC2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000707 meiotic DNA recombinase assembly IBA
 biological_processGO:0000724 double-strand break repair via homologous recombination ISO
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007131 reciprocal meiotic recombination IBA
 biological_processGO:0010165 response to X-ray IMP
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0035264 multicellular organism growth IGI
 biological_processGO:0042148 strand invasion IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:2000269 regulation of fibroblast apoptotic process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IBA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000150 recombinase activity IBA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Trp53tm1Tyj/Trp53+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Allelic Composition: Trp53tm1Tyj/Trp53+,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Trp53tm1Tyj/Trp53+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53+,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53+,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53+,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Xrcc2tm1Pmc/Xrcc2tm1Pmc,Atmtm1Pmc/Atmtm1Pmc
Genetic Background: involves: 129S1/Sv

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / reaction / complex
 ENSMUSG00000018841 O55230 / Rad51d / RAD51 paralog D / O75771*  / complex / reaction
 ENSMUSG00000059060 O35719 / Rad51b / DNA repair 2 / O15315* / RAD51 paralog B*  / reaction / complex
 ENSMUSG00000044702 Palb2 / Q3U0P1 / Partner and localizer of BRCA2 / Q86YC2*  / reaction
 ENSMUSG00000030346 Rad51ap1 / RAD51-associated protein 1 isoform 2 / Q96B01* / RAD51 associated protein 1*  / reaction






 

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