Manteia

ENSMUSG00000059060

Mus musculus

Features

Gene ID:	ENSMUSG00000059060

Biological name :	Rad51b

Synonyms :	DNA repair 2 / O35719 / Rad51b

Possible biological names infered from orthology :	O15315 / RAD51 paralog B

Species:	Mus musculus

Chr. number:	12
Strand:	1
Band:	C3
Gene start:	79297282
Gene end:	79814690

Corresponding Affymetrix probe sets:	10396849 (MoGene1.0st) 1421430_at (Mouse Genome 430 2.0 Array) 1430486_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000078490 Ensembl peptide - ENSMUSP00000128357 Ensembl peptide - ENSMUSP00000152105 NCBI entrez gene - 19363 See in Manteia. MGI - MGI:1099436 RefSeq - XM_017315003 RefSeq - NM_001252562 RefSeq - NM_009014 RefSeq - XM_017315000 RefSeq - XM_017315001 RefSeq - XM_017315002 RefSeq - XM_006515622 RefSeq - XM_006515623 RefSeq - XM_006515624 RefSeq - XM_006515625 RefSeq - XM_011244022 RefSeq - XM_011244026 RefSeq - XM_011244027 RefSeq - XM_011244028 RefSeq - XM_011244029 RefSeq - XM_011244030 RefSeq - XM_011244031 RefSeq - XM_011244032 RefSeq - XM_011244033 RefSeq - XM_011244034 RefSeq - XM_011244035 RefSeq - XM_011244036 RefSeq - XM_011244039 RefSeq - XM_011244040 RefSeq - XM_011244045 RefSeq Peptide - NP_033040 RefSeq Peptide - NP_001239491 swissprot - O35719 Ensembl - ENSMUSG00000059060

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rad51b	ENSDARG00000037046	Danio rerio
RAD51B	ENSGALG00000009491	Gallus gallus
O15315	ENSG00000182185	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*	ENSMUSG00000021287	28
O55230 / Rad51d / RAD51 paralog D / O75771*	ENSMUSG00000018841	27
Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*	ENSMUSG00000007646	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR003593	AAA+ ATPase domain
IPR013632	DNA recombination and repair protein Rad51-like, C-terminal
IPR016467	DNA recombination and repair protein, RecA-like
IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR030548	DNA repair protein RAD51 homologue 2
IPR033925	Rad51/DMC1/RadA

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000707	meiotic DNA recombinase assembly	IBA
biological_process	GO:0000724	double-strand break repair via homologous recombination	ISS
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0001832	blastocyst growth	IMP
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006310	DNA recombination	IEA
biological_process	GO:0006312	mitotic recombination	IBA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0007131	reciprocal meiotic recombination	IBA
biological_process	GO:0008284	positive regulation of cell proliferation	IMP
biological_process	GO:0010212	response to ionizing radiation	IBA
biological_process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	ISS
biological_process	GO:0042148	strand invasion	IBA
biological_process	GO:0061053	somite development	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005657	replication fork	IBA
cellular_component	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	ISO
molecular_function	GO:0000150	recombinase activity	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0000400	four-way junction DNA binding	IBA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003690	double-stranded DNA binding	ISS
molecular_function	GO:0003697	single-stranded DNA binding	IBA
molecular_function	GO:0004520	endodeoxyribonuclease activity	IBA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008094	DNA-dependent ATPase activity	IBA

Pathways (from Reactome)

Pathway description

HDR through Homologous Recombination (HRR)

Resolution of D-loop Structures through Holliday Junction Intermediates

Homologous DNA Pairing and Strand Exchange

Presynaptic phase of homologous DNA pairing and strand exchange

Factors involved in megakaryocyte development and platelet production

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0006206	embryonic lethality before turning of embryo	"death anytime after somite formation but before embryo turning (E8 to less than E9)" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hck^tm1Hev/Hck^tm1Hev,Src^tm1Sor/Src^tm1Sor Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Hck^tm1Hev/Hck^tm1Hev,Src^tm1Sor/Src^tm1Sor Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000007646	Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*	/ complex / reaction
ENSMUSG00000018841	O55230 / Rad51d / RAD51 paralog D / O75771*	/ complex / reaction
ENSMUSG00000028933	Xrcc2 / Q9CX47 / X-ray repair complementing defective repair in Chinese hamster cells 2 / O43543* / X-ray repair cross complementing 2*	/ complex / reaction
ENSMUSG00000044702	Palb2 / Q3U0P1 / Partner and localizer of BRCA2 / Q86YC2*	/ reaction
ENSMUSG00000030346	Rad51ap1 / RAD51-associated protein 1 isoform 2 / Q96B01* / RAD51 associated protein 1*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr