ENSMUSG00000021287


Mus musculus

Features
Gene ID: ENSMUSG00000021287
  
Biological name :Xrcc3
  
Synonyms : Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / Xrcc3
  
Possible biological names infered from orthology : O43542 / X-ray repair cross complementing 3
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 111803192
Gene end: 111813873
  
Corresponding Affymetrix probe sets: 10402721 (MoGene1.0st)   1437623_x_at (Mouse Genome 430 2.0 Array)   1452748_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021715
Ensembl peptide - ENSMUSP00000118040
NCBI entrez gene - 74335     See in Manteia.
MGI - MGI:1921585
RefSeq - XM_006516300
RefSeq - NM_028875
RefSeq Peptide - NP_083151
swissprot - Q80W51
swissprot - Q9CXE6
Ensembl - ENSMUSG00000021287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc3ENSDARG00000017928Danio rerio
 XRCC3ENSGALG00000011533Gallus gallus
 XRCC3ENSG00000126215Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*ENSMUSG0000000764623
O35719 / Rad51b / DNA repair 2 / O15315* / RAD51 paralog B*ENSMUSG0000005906020
O55230 / Rad51d / RAD51 paralog D / O75771*ENSMUSG0000001884119


Protein motifs (from Interpro)
Interpro ID Name
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033925  Rad51/DMC1/RadA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000707 meiotic DNA recombinase assembly IBA
 biological_processGO:0000722 telomere maintenance via recombination IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007131 reciprocal meiotic recombination IBA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0010824 regulation of centrosome duplication IEA
 biological_processGO:0036297 interstrand cross-link repair IEA
 biological_processGO:0042148 strand invasion IBA
 biological_processGO:0071140 resolution of mitotic recombination intermediates IEA
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
 biological_processGO:0090656 t-circle formation IEA
 biological_processGO:0090737 telomere maintenance via telomere trimming IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
 cellular_componentGO:0033065 Rad51C-XRCC3 complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000150 recombinase activity IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IEA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / complex / reaction
 ENSMUSG00000024906 Mus81 / Q91ZJ0 / Crossover junction endonuclease MUS81 / Q96NY9* / MUS81 structure-specific endonuclease subunit*  / reaction
 ENSMUSG00000039055 Eme1 / Q8BJW7 / Crossover junction endonuclease EME1 / Q96AY2* / essential meiotic structure-specific endonuclease 1*  / reaction
 ENSMUSG00000039738 Slx4 / Q6P1D7 / Structure-specific endonuclease subunit SLX4 / Q8IY92* / SLX4 structure-specific endonuclease subunit*  / reaction
 ENSMUSG00000059772 Slx1b / Q8BX32 / SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) / SLX1A* / Q9BQ83* / SLX1 homolog A, structure-specific endonuclease subunit* / SLX1 homolog B, struc...  / reaction
 ENSMUSG00000051235 Gen1 / Q8BMI4 / Flap endonuclease GEN homolog 1 / Q17RS7* / GEN1, Holliday junction 5 flap endonuclease*  / reaction






 

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