ENSMUSG00000051235


Mus musculus

Features
Gene ID: ENSMUSG00000051235
  
Biological name :Gen1
  
Synonyms : Flap endonuclease GEN homolog 1 / Gen1 / Q8BMI4
  
Possible biological names infered from orthology : GEN1, Holliday junction 5 flap endonuclease / Q17RS7
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 11238920
Gene end: 11265801
  
Corresponding Affymetrix probe sets: 10399391 (MoGene1.0st)   1436654_at (Mouse Genome 430 2.0 Array)   1458373_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151310
Ensembl peptide - ENSMUSP00000151898
Ensembl peptide - ENSMUSP00000151740
Ensembl peptide - ENSMUSP00000151650
Ensembl peptide - ENSMUSP00000132098
NCBI entrez gene - 209334     See in Manteia.
MGI - MGI:2443149
RefSeq - XM_006515039
RefSeq - XM_006515041
RefSeq - XM_006515042
RefSeq - XM_011243851
RefSeq - XM_011243852
RefSeq - XM_006515040
RefSeq - NM_177331
RefSeq Peptide - NP_796305
swissprot - Q8BMI4
swissprot - A0A1W2P7L4
swissprot - A0A1W2P7J7
swissprot - A0A1W2P6M6
swissprot - A0A1W2P876
Ensembl - ENSMUSG00000051235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO834823.1ENSDARG00000112451Danio rerio
 ENSGALG00000031032Gallus gallus
 ENSGALG00000016468Gallus gallus
 GEN1ENSG00000178295Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fen1 / flap structure-specific endonuclease 1 / P39748*ENSMUSG000000247429


Protein motifs (from Interpro)
Interpro ID Name
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR029060  PIN-like domain superfamily
 IPR036279  5"-3" exonuclease, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010824 regulation of centrosome duplication IEA
 biological_processGO:0071139 resolution of recombination intermediates IEA
 biological_processGO:0071140 resolution of mitotic recombination intermediates IEA
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / reaction
 ENSMUSG00000021287 Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*  / reaction






 

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