ENSG00000178295


Homo sapiens

Features
Gene ID: ENSG00000178295
  
Biological name :GEN1
  
Synonyms : GEN1 / GEN1, Holliday junction 5 flap endonuclease / Q17RS7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p24.2
Gene start: 17753858
Gene end: 17788941
  
Corresponding Affymetrix probe sets: 1557267_s_at (Human Genome U133 Plus 2.0 Array)   228286_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481385
Ensembl peptide - ENSP00000318977
Ensembl peptide - ENSP00000370653
Ensembl peptide - ENSP00000433180
Ensembl peptide - ENSP00000435143
NCBI entrez gene - 348654     See in Manteia.
OMIM - 612449
RefSeq - XM_011532822
RefSeq - NM_001130009
RefSeq - NM_182625
RefSeq - XM_005262613
RefSeq - XM_006712005
RefSeq - XM_011532820
RefSeq - XM_011532821
RefSeq Peptide - NP_001123481
RefSeq Peptide - NP_872431
swissprot - E9PM30
swissprot - E9PLG0
swissprot - Q17RS7
swissprot - A0A087WXY3
Ensembl - ENSG00000178295
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO834823.1ENSDARG00000112451Danio rerio
 ENSGALG00000031032Gallus gallus
 ENSGALG00000016468Gallus gallus
 Gen1ENSMUSG00000051235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FEN1 / P39748 / flap structure-specific endonuclease 1ENSG0000016849610


Protein motifs (from Interpro)
Interpro ID Name
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR029060  PIN-like domain superfamily
 IPR036279  5"-3" exonuclease, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010824 regulation of centrosome duplication IMP
 biological_processGO:0071139 resolution of recombination intermediates IMP
 biological_processGO:0071140 resolution of mitotic recombination intermediates IMP
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity TAS
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / reaction
 ENSG00000126215 XRCC3 / O43542 / X-ray repair cross complementing 3  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr