ENSMUSG00000007646


Mus musculus

Features
Gene ID: ENSMUSG00000007646
  
Biological name :Rad51c
  
Synonyms : DNA repair 3 / Q924H5 / Rad51c
  
Possible biological names infered from orthology : O43502 / RAD51 paralog C
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 87376645
Gene end: 87404954
  
Corresponding Affymetrix probe sets: 10389627 (MoGene1.0st)   1423026_at (Mouse Genome 430 2.0 Array)   1438453_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007790
Ensembl peptide - ENSMUSP00000064079
Ensembl peptide - ENSMUSP00000121928
Ensembl peptide - ENSMUSP00000122811
NCBI entrez gene - 114714     See in Manteia.
MGI - MGI:2150020
RefSeq - NM_053269
RefSeq - XM_006532009
RefSeq - NM_001291440
RefSeq Peptide - NP_001278369
RefSeq Peptide - NP_444499
swissprot - F2Z433
swissprot - Q924H5
swissprot - F2Z4A1
Ensembl - ENSMUSG00000007646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad51cENSDARG00000068919Danio rerio
 RAD51CENSGALG00000040380Gallus gallus
 O43502ENSG00000108384Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*ENSMUSG0000002128721
O55230 / Rad51d / RAD51 paralog D / O75771*ENSMUSG0000001884119
O35719 / Rad51b / DNA repair 2 / O15315* / RAD51 paralog B*ENSMUSG0000005906016


Protein motifs (from Interpro)
Interpro ID Name
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033925  Rad51/DMC1/RadA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000707 meiotic DNA recombinase assembly IBA
 biological_processGO:0000722 telomere maintenance via recombination IGI
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007066 female meiosis sister chromatid cohesion IMP
 biological_processGO:0007131 reciprocal meiotic recombination IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0042148 strand invasion IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex IEA
 cellular_componentGO:0033065 Rad51C-XRCC3 complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0048476 Holliday junction resolvase complex IEA
 molecular_functionGO:0000150 recombinase activity IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IEA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Sufutm1.1Blnw/Sufutm1.1Blnw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Sufutm1.1Blnw/Sufutm1.1Blnw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sufutm1.1Blnw/Sufutm1.1Blnw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028933 Xrcc2 / Q9CX47 / X-ray repair complementing defective repair in Chinese hamster cells 2 / O43543* / X-ray repair cross complementing 2*  / reaction / complex
 ENSMUSG00000059060 O35719 / Rad51b / DNA repair 2 / O15315* / RAD51 paralog B*  / complex / reaction
 ENSMUSG00000018841 O55230 / Rad51d / RAD51 paralog D / O75771*  / reaction / complex
 ENSMUSG00000021287 Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*  / reaction / complex
 ENSMUSG00000024906 Mus81 / Q91ZJ0 / Crossover junction endonuclease MUS81 / Q96NY9* / MUS81 structure-specific endonuclease subunit*  / reaction
 ENSMUSG00000039055 Eme1 / Q8BJW7 / Crossover junction endonuclease EME1 / Q96AY2* / essential meiotic structure-specific endonuclease 1*  / reaction
 ENSMUSG00000039738 Slx4 / Q6P1D7 / Structure-specific endonuclease subunit SLX4 / Q8IY92* / SLX4 structure-specific endonuclease subunit*  / reaction
 ENSMUSG00000044702 Palb2 / Q3U0P1 / Partner and localizer of BRCA2 / Q86YC2*  / reaction
 ENSMUSG00000059772 Slx1b / Q8BX32 / SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) / SLX1A* / Q9BQ83* / SLX1 homolog A, structure-specific endonuclease subunit* / SLX1 homolog B, struc...  / reaction
 ENSMUSG00000030346 Rad51ap1 / RAD51-associated protein 1 isoform 2 / Q96B01* / RAD51 associated protein 1*  / reaction
 ENSMUSG00000051235 Gen1 / Q8BMI4 / Flap endonuclease GEN homolog 1 / Q17RS7* / GEN1, Holliday junction 5 flap endonuclease*  / reaction






 

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