ENSMUSG00000059772


Mus musculus

Features
Gene ID: ENSMUSG00000059772
  
Biological name :Slx1b
  
Synonyms : Q8BX32 / Slx1b / SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
  
Possible biological names infered from orthology : Q9BQ83 / SLX1A / SLX1 homolog A, structure-specific endonuclease subunit / SLX1 homolog B, structure-specific endonuclease subunit
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126689468
Gene end: 126695784
  
Corresponding Affymetrix probe sets: 10568017 (MoGene1.0st)   1454082_a_at (Mouse Genome 430 2.0 Array)   1455219_at (Mouse Genome 430 2.0 Array)   1460095_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118182
Ensembl peptide - ENSMUSP00000117927
NCBI entrez gene - 75764     See in Manteia.
MGI - MGI:1915220
RefSeq - NM_029420
RefSeq Peptide - NP_083696
swissprot - D6RE55
swissprot - Q8BX32
Ensembl - ENSMUSG00000059772
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slx1bENSDARG00000098605Danio rerio
 ENSGALG00000044283Gallus gallus
 SLX1AENSG00000132207Homo sapiens
 SLX1BENSG00000181625Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000305  GIY-YIG endonuclease
 IPR027520  Structure-specific endonuclease subunit Slx1
 IPR035901  GIY-YIG endonuclease superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090656 t-circle formation IMP
 biological_processGO:1904431 positive regulation of t-circle formation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0033557 Slx1-Slx4 complex ISO
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fan1tm1.1Jrou/Fan1tm1.1Jrou,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024906 Mus81 / Q91ZJ0 / Crossover junction endonuclease MUS81 / Q96NY9* / MUS81 structure-specific endonuclease subunit*  / complex / reaction
 ENSMUSG00000039055 Eme1 / Q8BJW7 / Crossover junction endonuclease EME1 / Q96AY2* / essential meiotic structure-specific endonuclease 1*  / complex / reaction
 ENSMUSG00000039738 Slx4 / Q6P1D7 / Structure-specific endonuclease subunit SLX4 / Q8IY92* / SLX4 structure-specific endonuclease subunit*  / complex
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / reaction
 ENSMUSG00000021287 Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*  / reaction






 

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