ENSG00000132207


Homo sapiens

Features
Gene ID: ENSG00000132207
  
Biological name :SLX1A
  
Synonyms : Q9BQ83 / SLX1A / SLX1 homolog A, structure-specific endonuclease subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 30193887
Gene end: 30197561
  
Corresponding Affymetrix probe sets: 218317_x_at (Human Genome U133 Plus 2.0 Array)   222094_at (Human Genome U133 Plus 2.0 Array)   233334_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000251303
Ensembl peptide - ENSP00000333945
Ensembl peptide - ENSP00000455250
NCBI entrez gene - 105369236     See in Manteia.
NCBI entrez gene - 548593     See in Manteia.
OMIM - 615822
RefSeq - XM_011508604
RefSeq - NM_001014999
RefSeq - NM_001015000
RefSeq Peptide - NP_001014999
RefSeq Peptide - NP_001015000
swissprot - Q9BQ83
swissprot - H3BPC3
Ensembl - ENSG00000132207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slx1bENSDARG00000098605Danio rerio
 ENSGALG00000044283Gallus gallus
 Slx1bENSMUSG00000059772Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLX1B / Q9BQ83 / SLX1 homolog B, structure-specific endonuclease subunitENSG00000181625100


Protein motifs (from Interpro)
Interpro ID Name
 IPR000305  GIY-YIG endonuclease
 IPR027520  Structure-specific endonuclease subunit Slx1
 IPR035901  GIY-YIG endonuclease superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing IMP
 biological_processGO:0010833 telomere maintenance via telomere lengthening IMP
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0061820 telomeric D-loop disassembly IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090656 t-circle formation ISS
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IMP
 biological_processGO:1904431 positive regulation of t-circle formation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0033557 Slx1-Slx4 complex TAS
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / reaction
 ENSG00000126215 XRCC3 / O43542 / X-ray repair cross complementing 3  / reaction
 ENSG00000172732 MUS81 / Q96NY9 / MUS81 structure-specific endonuclease subunit  / reaction / complex
 ENSG00000188827 SLX4 / Q8IY92 / SLX4 structure-specific endonuclease subunit  / complex
 ENSG00000154920 EME1 / Q96AY2 / essential meiotic structure-specific endonuclease 1  / complex / reaction






 

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