ENSG00000172732


Homo sapiens

Features
Gene ID: ENSG00000172732
  
Biological name :MUS81
  
Synonyms : MUS81 / MUS81 structure-specific endonuclease subunit / Q96NY9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 65857126
Gene end: 65867653
  
Corresponding Affymetrix probe sets: 218463_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432287
Ensembl peptide - ENSP00000433473
Ensembl peptide - ENSP00000435277
Ensembl peptide - ENSP00000434305
Ensembl peptide - ENSP00000433809
Ensembl peptide - ENSP00000307853
Ensembl peptide - ENSP00000431478
Ensembl peptide - ENSP00000431979
NCBI entrez gene - 80198     See in Manteia.
OMIM - 606591
RefSeq - XM_011545270
RefSeq - NM_001350283
RefSeq - NM_025128
RefSeq - XM_005274307
RefSeq - XM_011545269
RefSeq Peptide - NP_001337212
RefSeq Peptide - NP_079404
swissprot - Q96NY9
swissprot - E9PRI1
swissprot - E9PL60
swissprot - E9PII7
swissprot - H0YDE3
swissprot - H0YDU2
swissprot - H0YDK3
swissprot - H0YE94
Ensembl - ENSG00000172732
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mus81ENSDARG00000069326Danio rerio
 Mus81ENSMUSG00000024906Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006166  ERCC4 domain
 IPR011335  Restriction endonuclease type II-like
 IPR027421  DNA polymerase lambda lyase domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000727 double-strand break repair via break-induced replication IBA
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IMP
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IBA
 biological_processGO:0031297 replication fork processing IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0072429 response to intra-S DNA damage checkpoint signaling IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0048476 Holliday junction resolvase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048257 3"-flap endonuclease activity IMP


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126215 XRCC3 / O43542 / X-ray repair cross complementing 3  / reaction
 ENSG00000188827 SLX4 / Q8IY92 / SLX4 structure-specific endonuclease subunit  / complex / reaction
 ENSG00000154920 EME1 / Q96AY2 / essential meiotic structure-specific endonuclease 1  / reaction / complex
 ENSG00000197774 EME2 / A4GXA9 / essential meiotic structure-specific endonuclease subunit 2  / complex
 ENSG00000132207 SLX1A / Q9BQ83 / SLX1 homolog A, structure-specific endonuclease subunit  / complex / reaction
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / reaction
 ENSG00000172732 MUS81 / Q96NY9 / MUS81 structure-specific endonuclease subunit  / reaction






 

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