ENSG00000197774


Homo sapiens

Features
Gene ID: ENSG00000197774
  
Biological name :EME2
  
Synonyms : A4GXA9 / EME2 / essential meiotic structure-specific endonuclease subunit 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 1773207
Gene end: 1781708
  
Corresponding Affymetrix probe sets: 1556024_at (Human Genome U133 Plus 2.0 Array)   1569867_at (Human Genome U133 Plus 2.0 Array)   1569868_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457966
Ensembl peptide - ENSP00000456946
Ensembl peptide - ENSP00000457353
NCBI entrez gene - 197342     See in Manteia.
OMIM - 610886
RefSeq - XM_017023026
RefSeq - NM_001257370
RefSeq - XM_017023025
RefSeq Peptide - NP_001244299
swissprot - A4GXA9
swissprot - H3BSZ6
swissprot - H3BV62
Ensembl - ENSG00000197774
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EME2ENSGALG00000002276Gallus gallus
 Eme2ENSMUSG00000073436Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EME1 / Q96AY2 / essential meiotic structure-specific endonuclease 1ENSG0000015492032


Protein motifs (from Interpro)
Interpro ID Name
 IPR006166  ERCC4 domain
 IPR033310  Mms4/EME1/EME2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031297 replication fork processing IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0048476 Holliday junction resolvase complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172732 MUS81 / Q96NY9 / MUS81 structure-specific endonuclease subunit  / complex






 

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