ENSG00000154920


Homo sapiens

Features
Gene ID: ENSG00000154920
  
Biological name :EME1
  
Synonyms : EME1 / essential meiotic structure-specific endonuclease 1 / Q96AY2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.33
Gene start: 50373220
Gene end: 50381483
  
Corresponding Affymetrix probe sets: 234464_s_at (Human Genome U133 Plus 2.0 Array)   234465_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425567
Ensembl peptide - ENSP00000423029
Ensembl peptide - ENSP00000427392
Ensembl peptide - ENSP00000339897
Ensembl peptide - ENSP00000376952
Ensembl peptide - ENSP00000421700
NCBI entrez gene - 146956     See in Manteia.
OMIM - 610885
RefSeq - XM_017024236
RefSeq - NM_001166131
RefSeq - NM_152463
RefSeq - XM_005257081
RefSeq - XM_011524395
RefSeq Peptide - NP_001159603
RefSeq Peptide - NP_689676
swissprot - F8W714
swissprot - H0Y9Z4
swissprot - Q96AY2
swissprot - D6RIT8
Ensembl - ENSG00000154920
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eme1ENSDARG00000076913Danio rerio
 EME1ENSGALG00000007676Gallus gallus
 Eme1ENSMUSG00000039055Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EME2 / A4GXA9 / essential meiotic structure-specific endonuclease subunit 2ENSG0000019777421


Protein motifs (from Interpro)
Interpro ID Name
 IPR006166  ERCC4 domain
 IPR033310  Mms4/EME1/EME2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031297 replication fork processing IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0072429 response to intra-S DNA damage checkpoint signaling IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005720 nuclear heterochromatin IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0048476 Holliday junction resolvase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172732 MUS81 / Q96NY9 / MUS81 structure-specific endonuclease subunit  / complex / reaction
 ENSG00000188827 SLX4 / Q8IY92 / SLX4 structure-specific endonuclease subunit  / reaction / complex
 ENSG00000126215 XRCC3 / O43542 / X-ray repair cross complementing 3  / reaction
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / reaction
 ENSG00000132207 SLX1A / Q9BQ83 / SLX1 homolog A, structure-specific endonuclease subunit  / reaction / complex






 

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