ENSMUSG00000039055


Mus musculus

Features
Gene ID: ENSMUSG00000039055
  
Biological name :Eme1
  
Synonyms : Crossover junction endonuclease EME1 / Eme1 / Q8BJW7
  
Possible biological names infered from orthology : essential meiotic structure-specific endonuclease 1 / Q96AY2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 94644996
Gene end: 94653964
  
Corresponding Affymetrix probe sets: 10390050 (MoGene1.0st)   1435054_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036361
NCBI entrez gene - 268465     See in Manteia.
MGI - MGI:3576783
RefSeq - XM_011249045
RefSeq - NM_177752
RefSeq - XM_006533408
RefSeq Peptide - NP_808420
swissprot - Q8BJW7
Ensembl - ENSMUSG00000039055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eme1ENSDARG00000076913Danio rerio
 EME1ENSGALG00000007676Gallus gallus
 EME1ENSG00000154920Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eme2 / Q56A04 / Probable crossover junction endonuclease EME2 / A4GXA9* / essential meiotic structure-specific endonuclease subunit 2*ENSMUSG0000007343620


Protein motifs (from Interpro)
Interpro ID Name
 IPR006166  ERCC4 domain
 IPR033310  Mms4/EME1/EME2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031297 replication fork processing IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0072429 response to intra-S DNA damage checkpoint signaling IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0048476 Holliday junction resolvase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024906 Mus81 / Q91ZJ0 / Crossover junction endonuclease MUS81 / Q96NY9* / MUS81 structure-specific endonuclease subunit*  / complex / reaction
 ENSMUSG00000039738 Slx4 / Q6P1D7 / Structure-specific endonuclease subunit SLX4 / Q8IY92* / SLX4 structure-specific endonuclease subunit*  / reaction / complex
 ENSMUSG00000059772 Slx1b / Q8BX32 / SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) / SLX1A* / Q9BQ83* / SLX1 homolog A, structure-specific endonuclease subunit* / SLX1 homolog B, struc...  / complex / reaction
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / reaction
 ENSMUSG00000021287 Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*  / reaction






 

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