ENSMUSG00000024906


Mus musculus

Features
Gene ID: ENSMUSG00000024906
  
Biological name :Mus81
  
Synonyms : Crossover junction endonuclease MUS81 / Mus81 / Q91ZJ0
  
Possible biological names infered from orthology : MUS81 structure-specific endonuclease subunit / Q96NY9
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5482345
Gene end: 5488402
  
Corresponding Affymetrix probe sets: 10465072 (MoGene1.0st)   1431885_a_at (Mouse Genome 430 2.0 Array)   1450432_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025841
Ensembl peptide - ENSMUSP00000114895
Ensembl peptide - ENSMUSP00000118580
Ensembl peptide - ENSMUSP00000121435
NCBI entrez gene - 71711     See in Manteia.
MGI - MGI:1918961
RefSeq - XM_006531838
RefSeq - NM_027877
RefSeq Peptide - NP_082153
swissprot - F6VIY4
swissprot - D6RCJ5
swissprot - Q91ZJ0
swissprot - F8WIN9
Ensembl - ENSMUSG00000024906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mus81ENSDARG00000069326Danio rerio
 MUS81ENSG00000172732Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006166  ERCC4 domain
 IPR011335  Restriction endonuclease type II-like
 IPR027421  DNA polymerase lambda lyase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000727 double-strand break repair via break-induced replication IBA
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IEA
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IBA
 biological_processGO:0031297 replication fork processing IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0072429 response to intra-S DNA damage checkpoint signaling IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0048476 Holliday junction resolvase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048257 3"-flap endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

Allelic Composition: Mus81tm1Esse/Mus81+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pitx1tm1Jdr/Pitx1+,Pitx2tm1Sac/Pitx2tm1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0003395 abnormal subclavian artery morphology "malformation of the right or left subclavian arteries, The right subclavian artery extends from the brachiocephalic artery to the right side of the body. The left subclavian artery extends from the aortic arch to the left side of the body." [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0006265 increased pulse pressure "increase in the difference between systolic and diastolic blood pressure" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Slx4tm1.2Jrou/Slx4tm1.2Jrou
Genetic Background: B6.129P2-Slx4tm1.2Jrou

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008775 abnormal heart ventricular pressure "any anomaly in the pressure within a cardiac ventricle" [MESH:G09.330.553.660.937]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mus81tm1Esse/Mus81+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi,Mus81tm1Chmg/Mus81tm1Chmg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N * FVB/N

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slx4tm1.2Jrou/Slx4tm1.2Jrou
Genetic Background: B6.129P2-Slx4tm1.2Jrou

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

Allelic Composition: Mus81tm1Esse/Mus81+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

Allelic Composition: Mus81tm1Esse/Mus81+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009871 abnormal aorta tunica adventitia morphology "any structural anomaly of the outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mus81tm1Esse/Mus81+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010468 abnormal thoracic aorta morphology "any structural anomaly of the part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com "MedicineNet.com"]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0010470 ascending aorta dilation "the luminal space of the ascending aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0010661 ascending aorta aneurysm "a protruding sac formed by the dilation of the wall of the of the part of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010996 increased aorta wall thickness "increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: GFF-Grhl3ct

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059772 Slx1b / Q8BX32 / SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) / SLX1A* / Q9BQ83* / SLX1 homolog A, structure-specific endonuclease subunit* / SLX1 homolog B, struc...  / reaction / complex
 ENSMUSG00000073436 Eme2 / Q56A04 / Probable crossover junction endonuclease EME2 / A4GXA9* / essential meiotic structure-specific endonuclease subunit 2*  / complex
 ENSMUSG00000039055 Eme1 / Q8BJW7 / Crossover junction endonuclease EME1 / Q96AY2* / essential meiotic structure-specific endonuclease 1*  / reaction / complex
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / reaction
 ENSMUSG00000024906 Mus81 / Q91ZJ0 / Crossover junction endonuclease MUS81 / Q96NY9* / MUS81 structure-specific endonuclease subunit*  / reaction
 ENSMUSG00000039738 Slx4 / Q6P1D7 / Structure-specific endonuclease subunit SLX4 / Q8IY92* / SLX4 structure-specific endonuclease subunit*  / reaction / complex
 ENSMUSG00000021287 Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*  / reaction






 

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