ENSMUSG00000039738


Mus musculus

Features
Gene ID: ENSMUSG00000039738
  
Biological name :Slx4
  
Synonyms : Q6P1D7 / Slx4 / Structure-specific endonuclease subunit SLX4
  
Possible biological names infered from orthology : Q8IY92 / SLX4 structure-specific endonuclease subunit
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 3979105
Gene end: 4003770
  
Corresponding Affymetrix probe sets: 10437292 (MoGene1.0st)   1435969_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130007
Ensembl peptide - ENSMUSP00000129144
Ensembl peptide - ENSMUSP00000131380
Ensembl peptide - ENSMUSP00000038871
Ensembl peptide - ENSMUSP00000126047
Ensembl peptide - ENSMUSP00000126423
NCBI entrez gene - 52864     See in Manteia.
MGI - MGI:106299
RefSeq - XM_011245949
RefSeq - XM_006522352
RefSeq - XM_006522353
RefSeq - XM_006522354
RefSeq - XM_006522355
RefSeq - XM_006522358
RefSeq - XM_006522359
RefSeq - XM_011245948
RefSeq - NM_177472
RefSeq - XM_006522349
RefSeq - XM_006522350
RefSeq Peptide - NP_803423
swissprot - F6XZI3
swissprot - F7A9G8
swissprot - F6R0R3
swissprot - E9PYE7
swissprot - Q6P1D7
swissprot - E9Q0M1
Ensembl - ENSMUSG00000039738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-44g23.2ENSDARG00000092927Danio rerio
 slx4ENSDARG00000061414Danio rerio
 SLX4ENSGALG00000031841Gallus gallus
 SLX4ENSG00000188827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR018574  Structure-specific endonuclease subunit Slx4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000706 meiotic DNA double-strand break processing IBA
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing IEA
 biological_processGO:0036297 interstrand cross-link repair IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0061820 telomeric D-loop disassembly IEA
 biological_processGO:0072429 response to intra-S DNA damage checkpoint signaling IEA
 biological_processGO:0090656 t-circle formation IEA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IEA
 biological_processGO:1904431 positive regulation of t-circle formation IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0033557 Slx1-Slx4 complex ISO
 cellular_componentGO:0048476 Holliday junction resolvase complex IEA
 cellular_componentGO:0070522 ERCC4-ERCC1 complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity ISO
 molecular_functionGO:0048257 3"-flap endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Slc38a10tm2a(EUCOMM)Wtsi/Slc38a10tm2a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Slc38a10tm2a(EUCOMM)Wtsi/H

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000439 enlarged skull 
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0000440 domed skull 
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0000917 obstructive hydrocephaly "hydrocephaly due to a block in cerebralspinal fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Slx4m1Btlr/Slx4m1Btlr
Genetic Background: C57BL/6J-Slx4m1Btlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001317 abnormal pupil morphology "structural anomaly of the central circular aperture of the iris through which light rays enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003671 abnormal eyelid opening 
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0006241 abnormal placement of pupils "abnormal location of the pupil so that it is not in the center of the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0008391 abnormal primordial germ cell morphology "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Fan1tm1.1Jrou/Fan1tm1.1Jrou,Slx4tm1.2Jrou/Slx4tm1.2Jrou
Genetic Background: involves: 129P2/OlaHsd

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Slx4tm1.2Jrou/Slx4tm1.2Jrou
Genetic Background: B6.129P2-Slx4tm1.2Jrou

 MP:0010102 increased caudal vertebrae number "increased number of the bony segments of the coccyx or tail" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Slx4tm1.2Jrou/Slx4tm1.2Jrou
Genetic Background: B6.129P2-Slx4tm1.2Jrou

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Slx4tm1.2Jrou/Slx4tm1.2Jrou
Genetic Background: B6.129P2-Slx4tm1.2Jrou

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024906 Mus81 / Q91ZJ0 / Crossover junction endonuclease MUS81 / Q96NY9* / MUS81 structure-specific endonuclease subunit*  / reaction / complex
 ENSMUSG00000039055 Eme1 / Q8BJW7 / Crossover junction endonuclease EME1 / Q96AY2* / essential meiotic structure-specific endonuclease 1*  / reaction / complex
 ENSMUSG00000021287 Xrcc3 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3 / O43542* / X-ray repair cross complementing 3*  / reaction
 ENSMUSG00000007646 Q924H5 / Rad51c / DNA repair 3 / O43502* / RAD51 paralog C*  / reaction
 ENSMUSG00000059772 Slx1b / Q8BX32 / SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) / SLX1A* / Q9BQ83* / SLX1 homolog A, structure-specific endonuclease subunit* / SLX1 homolog B, struc...  / complex






 

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