ENSDARG00000061414


Danio rerio

Features
Gene ID: ENSDARG00000061414
  
Biological name :slx4
  
Synonyms : slx4 / SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
  
Possible biological names infered from orthology : Q6P1D7 / Q8IY92 / SLX4 structure-specific endonuclease subunit / Structure-specific endonuclease subunit SLX4
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 26798853
Gene end: 26844334
  
Corresponding Affymetrix probe sets: Dr.22272.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000122025
Ensembl peptide - ENSDARP00000152101
Ensembl peptide - ENSDARP00000082010
NCBI entrez gene - 100538153     See in Manteia.
RefSeq - XM_003201098
RefSeq - XM_021469609
swissprot - F1QPU2
swissprot - F1QUW5
ZFIN ID - ZDB-GENE-050208-359
Ensembl - ENSDARG00000061414
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLX4ENSGALG00000031841Gallus gallus
 SLX4ENSG00000188827Homo sapiens
 Slx4ENSMUSG00000039738Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-44g23.2 / SLX4* / Q8IY92* / Q6P1D7* / SLX4 structure-specific endonuclease subunit* / Structure-specific endonuclease subunit SLX4 *ENSDARG0000009292710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013087  Zinc finger C2H2-type
 IPR018574  Structure-specific endonuclease subunit Slx4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000706 meiotic DNA double-strand break processing IBA
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0036297 interstrand cross-link repair IBA
 biological_processGO:0061008 hepaticobiliary system development IMP
 biological_processGO:0061010 gall bladder development IMP
 biological_processGO:0061011 hepatic duct development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0033557 Slx1-Slx4 complex IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IBA
 molecular_functionGO:0017108 5"-flap endonuclease activity IBA
 molecular_functionGO:0048257 3"-flap endonuclease activity IBA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver hypoplastic , abnormal
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 ZFA:0000208 gall bladder gall bladder hypoplastic , abnormal
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 ZFA:0001338 intestine intestine hypoplastic , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 embryonic viscerocranium morphogenesis delayed , abnormal
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 ZFA:0005169 intrahepatic bile duct intrahepatic bile duct absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076913 eme1 / essential meiotic structure-specific endonuclease 1 / Q8BJW7* / Q96AY2* / Crossover junction endonuclease EME1 *  / complex / reaction
 ENSDARG00000069326 mus81 / MUS81 structure-specific endonuclease subunit / Q91ZJ0* / Q96NY9* / Crossover junction endonuclease MUS81 *  / complex / reaction
 ENSDARG00000098605 slx1b / SLX1 homolog B, structure-specific endonuclease subunit / SLX1A* / Q9BQ83* / Q8BX32* / SLX1 homolog A, structure-specific endonuclease subunit* / SLX1 structure-specific endonucleas...  / complex






 

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