ENSG00000181625


Homo sapiens

Features
Gene ID: ENSG00000181625
  
Biological name :SLX1B
  
Synonyms : Q9BQ83 / SLX1B / SLX1 homolog B, structure-specific endonuclease subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 29454501
Gene end: 29458219
  
Corresponding Affymetrix probe sets: 218317_x_at (Human Genome U133 Plus 2.0 Array)   222094_at (Human Genome U133 Plus 2.0 Array)   233334_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328940
Ensembl peptide - ENSP00000335316
Ensembl peptide - ENSP00000456372
NCBI entrez gene - 105369236     See in Manteia.
NCBI entrez gene - 79008     See in Manteia.
OMIM - 615823
RefSeq - XM_011508604
RefSeq - NM_024044
RefSeq - NM_178044
RefSeq - XM_011508603
RefSeq Peptide - NP_835145
RefSeq Peptide - NP_076949
swissprot - Q9BQ83
swissprot - H3BRR6
Ensembl - ENSG00000181625
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slx1bENSDARG00000098605Danio rerio
 ENSGALG00000044283Gallus gallus
 Slx1bENSMUSG00000059772Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLX1A / Q9BQ83 / SLX1 homolog A, structure-specific endonuclease subunitENSG00000132207100


Protein motifs (from Interpro)
Interpro ID Name
 IPR000305  GIY-YIG endonuclease
 IPR027520  Structure-specific endonuclease subunit Slx1
 IPR035901  GIY-YIG endonuclease superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing IMP
 biological_processGO:0010833 telomere maintenance via telomere lengthening IMP
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0061820 telomeric D-loop disassembly IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090656 t-circle formation ISS
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IMP
 biological_processGO:1904431 positive regulation of t-circle formation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0033557 Slx1-Slx4 complex TAS
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr