ENSG00000182185


Homo sapiens

Features
Gene ID: ENSG00000182185
  
Biological name :RAD51B
  
Synonyms : O15315 / RAD51B / RAD51 paralog B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q24.1
Gene start: 67819779
Gene end: 68730218
  
Corresponding Affymetrix probe sets: 1554496_at (Human Genome U133 Plus 2.0 Array)   1561122_a_at (Human Genome U133 Plus 2.0 Array)   210255_at (Human Genome U133 Plus 2.0 Array)   216880_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419881
Ensembl peptide - ENSP00000419471
Ensembl peptide - ENSP00000420061
Ensembl peptide - ENSP00000452044
Ensembl peptide - ENSP00000451616
Ensembl peptide - ENSP00000375101
Ensembl peptide - ENSP00000417408
Ensembl peptide - ENSP00000417948
Ensembl peptide - ENSP00000418859
NCBI entrez gene - 5890     See in Manteia.
OMIM - 602948
RefSeq - NM_133510
RefSeq - NM_001321809
RefSeq - NM_001321810
RefSeq - NM_001321812
RefSeq - NM_001321814
RefSeq - NM_001321815
RefSeq - NM_001321817
RefSeq - NM_001321818
RefSeq - NM_001321819
RefSeq - NM_001321821
RefSeq - NM_002877
RefSeq - NM_133509
RefSeq - XM_011537050
RefSeq - XM_011537051
RefSeq - XM_017021545
RefSeq - XM_017021547
RefSeq Peptide - NP_598194
RefSeq Peptide - NP_001308744
RefSeq Peptide - NP_001308746
RefSeq Peptide - NP_001308747
RefSeq Peptide - NP_001308748
RefSeq Peptide - NP_001308750
RefSeq Peptide - NP_002868
RefSeq Peptide - NP_598193
RefSeq Peptide - NP_001308738
RefSeq Peptide - NP_001308739
RefSeq Peptide - NP_001308741
RefSeq Peptide - NP_001308743
swissprot - A0A0A0MS18
swissprot - H0YJI5
swissprot - O15315
swissprot - C9JYJ0
swissprot - C9J5S9
swissprot - F8WAY6
swissprot - G3V4W9
Ensembl - ENSG00000182185
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad51bENSDARG00000037046Danio rerio
 RAD51BENSGALG00000009491Gallus gallus
 O35719ENSMUSG00000059060Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43502 / RAD51C / RAD51 paralog CENSG0000010838421
O75771 / RAD51D / RAD51 paralog DENSG0000018537920
XRCC3 / O43542 / X-ray repair cross complementing 3ENSG0000012621520


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030548  DNA repair protein RAD51 homologue 2
 IPR033925  Rad51/DMC1/RadA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000707 meiotic DNA recombinase assembly IBA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0000731 DNA synthesis involved in DNA repair TAS
 biological_processGO:0000732 strand displacement TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007131 reciprocal meiotic recombination TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0042148 strand invasion IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex IEA
 molecular_functionGO:0000150 recombinase activity IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / reaction / complex
 ENSG00000185379 O75771 / RAD51D / RAD51 paralog D  / complex / reaction
 ENSG00000111247 Q96B01 / RAD51AP1 / RAD51 associated protein 1  / reaction
 ENSG00000196584 XRCC2 / O43543 / X-ray repair cross complementing 2  / complex / reaction
 ENSG00000083093 PALB2 / Q86YC2 / partner and localizer of BRCA2  / reaction






 

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contact: otassy@igbmc.fr