MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0000157 | abnormal sternum morphology | "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/? Genetic Background: involves: 129 * C57BL/6 * DBA
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MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0000628 | abnormal mammary gland development | "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0000639 | abnormal adrenal gland morphology | "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0000662 | abnormal branching of the mammary ductal tree | "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
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MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/? Genetic Background: involves: 129 * C57BL/6 * DBA
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MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
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MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+ Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0001127 | small ovary | "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001130 | abnormal ovarian folliculogenesis | "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0001131 | abnormal ovarian follicles | "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0001132 | absent mature ovarian follicles | "failure of ovarian follicle differentiation" [J:35782] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0001134 | absent corpora lutea | "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0001140 | abnormal vaginal epithelium | "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001158 | abnormal prostate morphology | "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: Spta1sph-ha/Spta1+ Genetic Background: involves: DBA/1J
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001231 | abnormal basal cell layer morphology | "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001236 | abnormal spinous layer morphology | "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001241 | absent cornified layer | "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/? Genetic Background: involves: 129 * C57BL/6 * DBA
Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001606 | impaired hematopoiesis | "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/? Genetic Background: involves: 129 * C57BL/6 * DBA
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MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Brca2tm1.1Brn/Brca2tm1.1Brn Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
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MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
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MP:0001829 | increased activated T cell number | "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA
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MP:0001883 | mammary adenocarcinoma | "higher than normal incidence of malignant tumors of the mammary gland" [J:62919] |
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Allelic Composition: Brca2tm1Brd/Brca2tm1Brd Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Brca2tm2Arge/Brca2tm2Arge,Waptm1(cre)Arge/Waptm1(cre)Arge Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
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MP:0002018 | malignant tumors | "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427] |
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Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
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MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA
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MP:0002021 | increased incidence of induced tumors | "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0002024 | T cell derived lymphoma | "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0002032 | sarcoma | "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
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MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Lipgtm1Chan/Lipg+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0002052 | decreased tumor incidence | "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+ Genetic Background: involves: 129P2/OlaHsd
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MP:0002060 | abnormal skin morphology | "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0 Genetic Background: involves: C57BL/6 * CBA/J
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MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+ Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0002080 | prenatal lethality | "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lipgtm1Chan/Lipg+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
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MP:0002084 | abnormal developmental patterning | "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
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MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca1tm1Arge/Brca1tm1Arge,Brca2tm1Arge/Brca2tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Allelic Composition: Brca2tm1Brd/Brca2tm1Brd Genetic Background: involves: 129S7/SvEvBrd
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MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Brca2tm1Brd/Brca2tm1Brd Genetic Background: involves: 129S7/SvEvBrd
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MP:0002114 | abnormal axial skeleton morphology | "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: 129S/SvEv-Brca2tm1Cam
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Brd/Brca2tm1Brd Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Brca2tm1Arge/Brca2tm2Arge Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm2Mak/Brca2tm2Mak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002396 | abnormal hematopoietic system morphology/development | "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/? Genetic Background: involves: 129 * C57BL/6 * DBA
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MP:0002777 | absent ovarian follicles | "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0003335 | exocrine pancreatic insufficiency | "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
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MP:0003448 | altered tumor morphology | "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
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MP:0003607 | abnormal prostate physiology | "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Spta1sph-ha/Spta1+ Genetic Background: involves: DBA/1J
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0003702 | abnormal chromosome morphology | "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm2Mak/Brca2tm2Mak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0003789 | osteosarcoma | "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Trp53tm1Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+ Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Brca2tm1.1Brn/Brca2tm1.1Brn Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: 129S/SvEv-Brca2tm1Cam
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MP:0003992 | increased mortality induced by ionizing radiation | "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0004024 | aneuploidy | "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm2Mak/Brca2tm2Mak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0004028 | chromosome breakage | "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd
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MP:0004046 | abnormal mitosis | "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: 129S/SvEv-Brca2tm1Cam
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MP:0004201 | fetal growth retardation | "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0004228 | decreased cellular sensitivity to ionizing radiation | "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA
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MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0004502 | decreased incidence of chemically-induced tumors | "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+ Genetic Background: involves: 129P2/OlaHsd
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MP:0004556 | enlarged allantois | "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
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MP:0004806 | absent germ cells | "absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
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MP:0004833 | ovary atrophy | "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0004894 | uterus atrophy | "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0004955 | increased thymus weight | "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
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MP:0005029 | abnormal amnion | "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
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MP:0005044 | sepsis | "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434] |
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Allelic Composition: Lipgtm1Chan/Lipg+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0005159 | azoospermia | "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+ Genetic Background: involves: 129P2/OlaHsd
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MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+ Genetic Background: involves: 129P2/OlaHsd
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MP:0006283 | medulloblastoma | "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Tyj/Trp53+,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53+,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0006413 | increased T cell apoptosis | "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm2Mak/Brca2tm2Mak Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008000 | ovary tumor | "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53tm1Brn/Trp53tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
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MP:0008008 | early cellular replicative senescence | "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0008058 | abnormal DNA repair | "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc,Trp53tm1Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
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MP:0008780 | pancreatic acinar cell carcinoma | "presence of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
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MP:0008813 | decreased common myeloid progenitor cell number | "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0008866 | chromosomal instability | "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840] |
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0008943 | increased sensitivity to induced cell death | "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc Genetic Background: involves: 129P2/OlaHsd * BALB/c
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MP:0009078 | adrenal gland hyperplasia | "overdevelopment or increased size, usually due to a increased number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0009151 | pancreatic ductal adenocarcinoma | "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750] |
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Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
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MP:0009219 | prostate intraepithelial neoplasia | "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Spta1sph-ha/Spta1+ Genetic Background: involves: DBA/1J
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0009431 | decreased fetal weight | "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0009674 | decreased birth weight | "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0009733 | absent nipple | "absence of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
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MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Allelic Composition: ApcMin/Apc+,Brca2tm1Mbn/Brca2+ Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin
Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc,Trp53tm1Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0010300 | increased skin tumor incidence | "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0010301 | increased stomach tumor incidence | "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc,Trp53tm1Tyj/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
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MP:0010308 | decreased tumor latency | "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lipgtm1Chan/Lipg+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0010948 | abnormal double-strand DNA break repair | "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: 129S/SvEv-Brca2tm1Cam
Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: 129S/SvEv-Brca2tm1Cam
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
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MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Brca2tm1Brd/Brca2tm1Brd Genetic Background: involves: 129S7/SvEvBrd
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MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Brca1tm1Arge/Brca1tm1Arge,Brca2tm1Arge/Brca2tm1Arge Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Brca2tm2Hst/Brca2tm2Hst Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Brca2tm1.1Brn/Brca2tm1.1Brn Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N
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MP:0011097 | complete embryonic lethality before turning of embryo | "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith] |
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+ Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+ Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Brca2tm1Mbn/Brca2tm1Mbn Genetic Background: C.129P2-Brca2tm1Mbn
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: 129S/SvEv-Brca2tm1Cam
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam Genetic Background: involves: 129S/SvEv * MF1
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MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/? Genetic Background: involves: C57BL/6 * FVB/N
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MP:0011197 | abnormal proamniotic cavity morphology | "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6] |
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Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0 Genetic Background: involves: 129 * C57BL/6J
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MP:0011704 | decreased fibroblast proliferation | "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Lipgtm1Chan/Lipg+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA
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MP:0013220 | increased pancreas apoptosis | "increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
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MP:0013236 | ovary degeneration | "a retrogressive impairment of function or destruction of one or both ovaries" [MGI:anna] |
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Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
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