ENSMUSG00000041147


Mus musculus

Features
Gene ID: ENSMUSG00000041147
  
Biological name :Brca2
  
Synonyms : Brca2 / Breast cancer type 2 susceptibility protein homolog / P97929
  
Possible biological names infered from orthology : BRCA2, DNA repair associated / P51587
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G3
Gene start: 150522630
Gene end: 150570329
  
Corresponding Affymetrix probe sets: 10527801 (MoGene1.0st)   1419076_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038576
Ensembl peptide - ENSMUSP00000144150
Ensembl peptide - ENSMUSP00000144676
NCBI entrez gene - 12190     See in Manteia.
MGI - MGI:109337
RefSeq - XM_017320629
RefSeq - NM_001081001
RefSeq - NM_009765
RefSeq - XM_006504907
RefSeq - XM_011241019
RefSeq - XM_011241020
RefSeq - XM_017320628
RefSeq - XM_006504906
RefSeq Peptide - NP_001074470
RefSeq Peptide - NP_033895
swissprot - P97929
swissprot - A0A0J9YVI7
Ensembl - ENSMUSG00000041147
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brca2ENSDARG00000079015Danio rerio
 BRCA2ENSGALG00000017073Gallus gallus
 BRCA2ENSG00000139618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002093  BRCA2 repeat
 IPR012340  Nucleic acid-binding, OB-fold
 IPR015187  BRCA2, OB1
 IPR015188  BRCA2, OB3
 IPR015205  Tower domain
 IPR015252  Breast cancer type 2 susceptibility protein, helical domain
 IPR015525  Breast cancer type 2 susceptibility protein
 IPR036315  BRCA2 helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0000722 telomere maintenance via recombination IGI
 biological_processGO:0000724 double-strand break repair via homologous recombination ISO
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007569 cell aging IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IGI
 biological_processGO:0010165 response to X-ray IMP
 biological_processGO:0010225 response to UV-C IMP
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0048478 replication fork protection IMP
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051298 centrosome duplication IEA
 biological_processGO:0070200 establishment of protein localization to telomere IDA
 biological_processGO:1990426 mitotic recombination-dependent replication fork processing IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000800 lateral element IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033593 BRCA2-MAGE-D1 complex IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0010484 H3 histone acetyltransferase activity IEA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0001140 abnormal vaginal epithelium "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Spta1sph-ha/Spta1+
Genetic Background: involves: DBA/1J

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001241 absent cornified layer "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Brca2tm1.1Brn/Brca2tm1.1Brn
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Brca2tm1Brd/Brca2tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Brca2tm2Arge/Brca2tm2Arge,Waptm1(cre)Arge/Waptm1(cre)Arge
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm1Arge/Brca1tm1Arge,Brca2tm1Arge/Brca2tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Brca2tm1Arge/Brca2tm1Arge,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Brca2tm1Brd/Brca2tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Brca2tm1Brd/Brca2tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Brd/Brca2tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm2Mak/Brca2tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0003335 exocrine pancreatic insufficiency "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0,Trp53tm3Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spta1sph-ha/Spta1+
Genetic Background: involves: DBA/1J

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm2Mak/Brca2tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Brca2tm1.1Brn/Brca2tm1.1Brn
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm2Mak/Brca2tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0004806 absent germ cells "absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Tyj/Trp53+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm2Mak/Brca2tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Tg(Krt18-EGFP,-TAg121)36Ysng/0,Trp53tm1Brn/Trp53tm2Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0008780 pancreatic acinar cell carcinoma "presence of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009078 adrenal gland hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0009151 pancreatic ductal adenocarcinoma "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750]
Show

Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2+,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spta1sph-ha/Spta1+
Genetic Background: involves: DBA/1J

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0009733 absent nipple "absence of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

Allelic Composition: ApcMin/Apc+,Brca2tm1Mbn/Brca2+
Genetic Background: B6.Cg-Brca2tm1Mbn ApcMin

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2+,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Brd/Brca2tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Brca1tm1Arge/Brca1tm1Arge,Brca2tm1Arge/Brca2tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Brca2tm1.1Brn/Brca2tm1.1Brn
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2a+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Brca2tm1Mbn/Brca2tm1Mbn
Genetic Background: C.129P2-Brca2tm1Mbn

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Fxntm2Mkn/Fxntm2.1Mkn,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0013220 increased pancreas apoptosis "increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Brn,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0013236 ovary degeneration "a retrogressive impairment of function or destruction of one or both ovaries" [MGI:anna]
Show

Allelic Composition: Brca2tm1Cbl/Brca2tm1Cbl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / reaction
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex
 ENSMUSG00000044702 Palb2 / Q3U0P1 / Partner and localizer of BRCA2 / Q86YC2*  / complex
 ENSMUSG00000030346 Rad51ap1 / RAD51-associated protein 1 isoform 2 / Q96B01* / RAD51 associated protein 1*  / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr