ENSGALG00000002781


Gallus gallus

Features
Gene ID: ENSGALG00000002781
  
Biological name :BRCA1
  
Synonyms : BRCA1 / breast cancer type 1 susceptibility protein
  
Possible biological names infered from orthology : BRCA1, DNA repair associated / Breast cancer type 1 susceptibility protein homolog / P38398 / P48754
  
Species: Gallus gallus
  
Chr. number: 27
Strand: -1
Band:
Gene start: 5573536
Gene end: 5593894
  
Corresponding Affymetrix probe sets: Gga.14834.1.S1_at (Chicken Array)   Gga.14834.1.S1_s_at (Chicken Array)   Gga.4493.1.S1_at (Chicken Array)   Gga.4493.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004383
NCBI entrez gene - 373983     See in Manteia.
RefSeq - XM_015299564
RefSeq - NM_204169
RefSeq - XM_015299562
RefSeq - XM_015299563
RefSeq - XM_015299561
RefSeq Peptide - NP_989500
swissprot - F1N8I5
Ensembl - ENSGALG00000002781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BRCA1ENSG00000012048Homo sapiens
 Brca1ENSMUSG00000017146Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001841  Zinc finger, RING-type
 IPR011364  Breast cancer type 1 susceptibility protein (BRCA1)
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR025994  BRCA1, serine-rich domain
 IPR031099  BRCA1-associated


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035066 positive regulation of histone acetylation IBA
 biological_processGO:0035067 negative regulation of histone acetylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043009 chordate embryonic development IBA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0071158 positive regulation of cell cycle arrest IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0031436 BRCA1-BARD1 complex IBA
 cellular_componentGO:0070531 BRCA1-A complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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