ENSMUSG00000060445


Mus musculus

Features
Gene ID: ENSMUSG00000060445
  
Biological name :Sycp2
  
Synonyms : Q9CUU3 / Sycp2 / Synaptonemal complex protein 2
  
Possible biological names infered from orthology : Q9BX26
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 178345293
Gene end: 178407685
  
Corresponding Affymetrix probe sets: 10490304 (MoGene1.0st)   1444122_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079909
Ensembl peptide - ENSMUSP00000116917
NCBI entrez gene - 320558     See in Manteia.
MGI - MGI:1933281
RefSeq - XM_017319021
RefSeq - NM_177191
RefSeq - XM_006500664
RefSeq - XM_017319020
RefSeq Peptide - NP_796165
swissprot - A2AJW3
swissprot - Q9CUU3
Ensembl - ENSMUSG00000060445
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sycp2ENSDARG00000088950Danio rerio
 SYCP2ENSGALG00000045232Gallus gallus
 SYCP2ENSG00000196074Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sycp2l / A0A0M3U1B0 / Synaptonemal complex protein 2-like / Q5T4T6*ENSMUSG0000003865113


Protein motifs (from Interpro)
Interpro ID Name
 IPR024832  Synaptonemal complex protein 2
 IPR024835  Synaptonemal complex protein 1/2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007143 female meiotic nuclear division IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0048808 male genitalia morphogenesis IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0000800 lateral element IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / reaction / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr