ENSGALG00000037686


Gallus gallus

Features
Gene ID: ENSGALG00000037686
  
Biological name :NBN
  
Synonyms : NBN / nibrin
  
Possible biological names infered from orthology : O60934 / Q9R207
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 124919221
Gene end: 124940667
  
Corresponding Affymetrix probe sets: Gga.196.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046502
Ensembl peptide - ENSGALP00000056425
NCBI entrez gene - 374246     See in Manteia.
RefSeq - XM_015282764
RefSeq - NM_204337
RefSeq - XM_015282762
RefSeq - XM_015282763
RefSeq Peptide - NP_989668
swissprot - A0A1D5PU23
swissprot - A0A1D5P1G5
Ensembl - ENSGALG00000037686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nbnENSDARG00000040303Danio rerio
 NBNENSG00000104320Homo sapiens
 NbnENSMUSG00000028224Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001357  BRCT domain
 IPR008984  SMAD/FHA domain superfamily
 IPR013908  DNA repair Nbs1, C-terminal
 IPR016592  Nibrin
 IPR032429  Nibrin, second BRCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001832 blastocyst growth IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0031860 telomeric 3" overhang formation IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090656 t-circle formation IEA
 biological_processGO:0090737 telomere maintenance via telomere trimming IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IEA
 biological_processGO:1904354 negative regulation of telomere capping IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030870 Mre11 complex IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:0042405 nuclear inclusion body IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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