ENSMUSG00000021936


Mus musculus

Features
Gene ID: ENSMUSG00000021936
  
Biological name :Mapk8
  
Synonyms : Mapk8 / Mitogen-activated protein kinase 8 / Q91Y86
  
Possible biological names infered from orthology : P45983
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 33377898
Gene end: 33447158
  
Corresponding Affymetrix probe sets: 10418879 (MoGene1.0st)   1420931_at (Mouse Genome 430 2.0 Array)   1420932_at (Mouse Genome 430 2.0 Array)   1437045_at (Mouse Genome 430 2.0 Array)   1440856_at (Mouse Genome 430 2.0 Array)   1457936_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107576
Ensembl peptide - ENSMUSP00000107575
Ensembl peptide - ENSMUSP00000153833
Ensembl peptide - ENSMUSP00000022504
Ensembl peptide - ENSMUSP00000107573
Ensembl peptide - ENSMUSP00000107574
NCBI entrez gene - 26419     See in Manteia.
MGI - MGI:1346861
RefSeq - XM_006519032
RefSeq - NM_001310452
RefSeq - NM_001310453
RefSeq - NM_001310454
RefSeq - NM_016700
RefSeq Peptide - NP_001297381
RefSeq Peptide - NP_001297382
RefSeq Peptide - NP_001297383
RefSeq Peptide - NP_057909
swissprot - Q544A0
swissprot - Q91Y86
swissprot - Q7TSJ7
swissprot - A6P3E4
swissprot - G3X8U9
swissprot - D3Z1Z4
Ensembl - ENSMUSG00000021936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK8ENSGALG00000006109Gallus gallus
 MAPK8ENSG00000107643Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk10 / mitogen-activated protein kinase 10 isoform 1x / P53779* / mitogen-activated protein kinase 10*ENSMUSG0000004670989
Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*ENSMUSG0000002036681
Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*ENSMUSG0000005343641
Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*ENSMUSG0000005313741
Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*ENSMUSG0000002261041
Mapk13 / Q9Z1B7 / Mitogen-activated protein kinase 13 / O15264*ENSMUSG0000000486439


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008351  Mitogen-activated protein (MAP) kinase, JNK
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007258 JUN phosphorylation IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0031063 regulation of histone deacetylation IEA
 biological_processGO:0031281 positive regulation of cyclase activity IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0046686 response to cadmium ion IGI
 biological_processGO:0048263 determination of dorsal identity ISO
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0061833 protein localization to tricellular tight junction IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071310 cellular response to organic substance IBA
 biological_processGO:0071732 cellular response to nitric oxide IMP
 biological_processGO:0071803 positive regulation of podosome assembly IMP
 biological_processGO:0090045 positive regulation of deacetylase activity IEA
 biological_processGO:0097150 neuronal stem cell population maintenance ISO
 biological_processGO:0097300 programmed necrotic cell death IMP
 biological_processGO:1902595 regulation of DNA replication origin binding IEA
 biological_processGO:2000017 positive regulation of determination of dorsal identity IDA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030424 axon IMP
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0097441 basal dendrite IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004705 JUN kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035033 histone deacetylase regulator activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA


Pathways (from Reactome)
Pathway description
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000478 delayed intestine development "slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: STOCK MitfMi-wh

Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: STOCK MitfMi-wh

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Mapk8tm1Flv/Mapk8tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006257 abnormal fungiform papillae "malformation, absence, or atypical size or shape of the mushroom-shaped papillae, which have a single tase bud at the tip, located mostly on the dorsal anterior portion of the tongue " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmpktm2Bew/Dmpk+
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008113 abnormal macrophage differentiation "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009603 absent keratohyalin granules "absence of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010715 coloboma of the retina "congenital defect of the retina in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9+
Genetic Background: B6.129S-Mapk9tm1Flv Mapk8tm1Flv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011709 increased fibroblast cell migration "greater frequency of or more rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

 MP:0012502 decreased hindbrain apoptosis "decrease in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0012504 increased forebrain apoptosis "increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8+,Mapk9tm1Mka/Mapk9tm1Mka
Genetic Background: involves: 129

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0012677 absent brain ventricles "absence of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
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Allelic Composition: Mapk8tm1Wag/Mapk8tm1Wag,Mapk9tm1Mka/Mapk9+
Genetic Background: involves: 129 * C57BL/6

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Kitltm1Pbes/Kitltm1Pbes
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002948 Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*  / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction
 ENSMUSG00000040093 Bmf / Mus musculus BCL2 modifying factor (Bmf), transcript variant 3, mRNA. / Q96LC9* / Bcl2 modifying factor*  / reaction
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction
 ENSMUSG00000052684 Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000027381 O54918 / Bcl2l11 / Bcl-2-like protein 11 / O43521* / BCL2 like 11*  / reaction
 ENSMUSG00000037032 Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*  / complex / reaction
 ENSMUSG00000027104 Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000033352 Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*  / reaction
 ENSMUSG00000050272 Dscam / Q9ERC8 / Down syndrome cell adhesion molecule homolog / O60469* / DS cell adhesion molecule*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction






 

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