ENSMUSG00000027381


Mus musculus

Features
Gene ID: ENSMUSG00000027381
  
Biological name :Bcl2l11
  
Synonyms : Bcl2l11 / Bcl-2-like protein 11 / O54918
  
Possible biological names infered from orthology : BCL2 like 11 / O43521
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 128126038
Gene end: 128162547
  
Corresponding Affymetrix probe sets: 10475866 (MoGene1.0st)   1426334_a_at (Mouse Genome 430 2.0 Array)   1435448_at (Mouse Genome 430 2.0 Array)   1435449_at (Mouse Genome 430 2.0 Array)   1456005_a_at (Mouse Genome 430 2.0 Array)   1456006_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019281
Ensembl peptide - ENSMUSP00000087062
Ensembl peptide - ENSMUSP00000099499
Ensembl peptide - ENSMUSP00000099500
Ensembl peptide - ENSMUSP00000105970
NCBI entrez gene - 12125     See in Manteia.
MGI - MGI:1197519
RefSeq - XM_006498617
RefSeq - NM_001284410
RefSeq - NM_001291016
RefSeq - NM_009754
RefSeq - NM_207680
RefSeq - NM_207681
RefSeq - XM_006498614
RefSeq - XM_006498615
RefSeq - XM_006498616
RefSeq Peptide - NP_997564
RefSeq Peptide - NP_001271339
RefSeq Peptide - NP_001277945
RefSeq Peptide - NP_033884
RefSeq Peptide - NP_997563
swissprot - O54918
swissprot - Q3U7X3
swissprot - Q542N5
swissprot - Q6PEB3
Ensembl - ENSMUSG00000027381
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O43521ENSG00000153094Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014771  Apoptosis, Bim N-terminal
 IPR015040  Bcl-x interacting, BH3 domain
 IPR017288  Bcl-2-like protein 11
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001776 leukocyte homeostasis IMP
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0001783 B cell apoptotic process IGI
 biological_processGO:0001822 kidney development IGI
 biological_processGO:0002260 lymphocyte homeostasis IMP
 biological_processGO:0002262 myeloid cell homeostasis IGI
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage ISO
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0032464 positive regulation of protein homooligomerization ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0035148 tube formation IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042981 regulation of apoptotic process IGI
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IDA
 biological_processGO:0043583 ear development IGI
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0046620 regulation of organ growth IMP
 biological_processGO:0048066 developmental pigmentation IGI
 biological_processGO:0048070 regulation of developmental pigmentation IGI
 biological_processGO:0048536 spleen development IGI
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0048563 post-embryonic animal organ morphogenesis IMP
 biological_processGO:0060139 positive regulation of apoptotic process by virus IDA
 biological_processGO:0060154 cellular process regulating host cell cycle in response to virus IDA
 biological_processGO:0070242 thymocyte apoptotic process IGI
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISO
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process IGI
 biological_processGO:1902263 apoptotic process involved in embryonic digit morphogenesis IGI
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process ISO
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005868 cytoplasmic dynein complex IDA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0097136 Bcl-2 family protein complex IMP
 cellular_componentGO:0097140 BIM-BCL-xl complex ISO
 cellular_componentGO:0097141 BIM-BCL-2 complex ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IMP
 molecular_functionGO:0070840 dynein complex binding IDA


Pathways (from Reactome)
Pathway description
Activation of BIM and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Genetic Background: C57BL/6-Bcl2l11tm1.1Boui

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Genetic Background: C57BL/6-Bcl2l11tm2.1Boui

Allelic Composition: Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: C57BL/6-Bcl2l11tm3.1Boui

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic Background: C57BL/6-Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm2.1Boui

 MP:0000394 absent melanin granules in hair follicle "missing pigment polymers in the hair follicles" [J:18378]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Atmintm1.2Jhh/Atmintm1.2Jhh,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+,Bmftm1Rjd/Bmf+
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm3.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm3.1Boui/Bcl2l11+,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npy1rtm1Mnak/Npy1rtm1Mnak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmintm1.2Jhh/Atmintm1.2Jhh,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0003537 hydrometrocolops "collection of fluid in the vagina; often due to a congenital obstruction" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: involves: 129S1/Sv

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Genetic Background: C57BL/6-Bcl2l11tm1.1Boui

Allelic Composition: Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
Genetic Background: C57BL/6-Bcl2l11tm2.1Boui

Allelic Composition: Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: C57BL/6-Bcl2l11tm3.1Boui

Allelic Composition: Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic Background: C57BL/6-Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Atmintm1.2Jhh/Atmintm1.2Jhh,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast/J

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

Allelic Composition: Atmintm1.2Jhh/Atmintm1.2Jhh,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast/J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0005068 abnormal NK cell morphology/development "anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Pmaip1tm1Ast/Pmaip1tm1Ast
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: involves: 129S1/Sv

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast/J

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Dmdmdx-4Cv/Dmdmdx-4Cv,Terctm1Rdp/Terctm1Rdp
Genetic Background: B6.Cg-Terctm1Rdp Dmdmdx-4Cv

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skor2Tn(sb-Tyr)1799B.CA3Ove/Skor2Tn(sb-Tyr)1799B.CA3Ove
Genetic Background: involves: FVB/N

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: involves: 129S1/Sv

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast/J

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast/J

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Aicdatm1(cre)Njen/Aicda+,Bcl2l11tm1Ast/Bcl2l11tm1Ast,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008206 increased B-2 cell number "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
Show

Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Dicer1tm1Mmk/Dicer1tm1Mmk,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Atmintm1.2Jhh/Atmintm1.2Jhh,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: involves: 129S1/Sv

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Gata1tm1.1Yen/Gata1tm1.1Yen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast/J

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd,Bmftm3.1Rjd/Bmftm3.1Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd Bmftm3.1Rjd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm2.1Rjd/Bmftm2.1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm2.1Rjd

 MP:0009341 decreased splenocyte apoptosis "reduction in the number of spleen cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oprm1tm1Lyu/Oprm1+
Genetic Background: involves: Black Swiss

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
Genetic Background: B6.129S6-Bcl2l11tm3Rjd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bmftm1Rjd/Bmftm1Rjd
Genetic Background: B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Atmintm1.1Jhh/Atmintm1.1Jhh,Cd79atm1(cre)Reth/Cd79a+,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Myo5argsc379/Myo5argsc379
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Bcl2l11tm4Rjd/Bcl2l11tm4Rjd
Genetic Background: B6.129S6-Bcl2l11tm4Rjd

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007659 Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*  / reaction / complex
 ENSMUSG00000024959 Bad / Q61337 / Bcl2-associated agonist of cell death / Q92934*  / reaction
 ENSMUSG00000057329 Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*  / complex / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr